LRRC15 Protein, Human, Recombinant (hFc)

LRRC15 (Leucine-Rich Repeat Containing 15) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The tumor antigen 15-leucine-rich repeat-containing membrane protein (LRRC15) is a transmembrane protein demonstrated to play important roles in cancer. LRRC15 is highly expressed in multiple solid tumor indications with limited normal tissue expression. It was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head, and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). The tumor antigen LRRC15, which is frequently overexpressed in multiple tumor types, as a repressor of cell death due to adenoviral p53.

Pack Size	Availability	Price/USD
100 μg	In stock	$ 333.00
200 μg	5 days	$ 589.00
500 μg	5 days	$ 1,250.00

Pack Size

Availability

Price/USD

Quantity

100 μg

In stock

$ 333.00

200 μg

5 days

$ 589.00

500 μg

5 days

$ 1,250.00

Biological Information

Immobilized Recombinant Human LRRC15 Protein (ECD, Fc Tag) at 2 μg/mL (100 μL/well) can bind Anti-LRRC15 Antibody（Samrotamab）, the EC50 is 6.5-20 ng/mL.

Description

Species	Human
Expression System	HEK293
Tag	hFc
Accession Number	Q8TF66-1
Synonyms	leucine rich repeat containing 15, LIB
Construction	A DNA sequence encoding the human LRRC15 (NP_570843.2) (Met1-Gly538) was expressed with the Fc region of human IgG1 at the C-terminus.
Protein Purity	> 85 % as determined by SDS-PAGE.
Molecular Weight	Approxiamtely 84.5 kDa

Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	LRRC15 (Leucine-Rich Repeat Containing 15) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The tumor antigen 15-leucine-rich repeat-containing membrane protein (LRRC15) is a transmembrane protein demonstrated to play important roles in cancer. LRRC15 is highly expressed in multiple solid tumor indications with limited normal tissue expression. It was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head, and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). The tumor antigen LRRC15, which is frequently overexpressed in multiple tumor types, as a repressor of cell death due to adenoviral p53.

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LRRC15 Protein, Human, Recombinant (hFc)

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