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DL-alpha-Tocopherol

Name: DL-alpha-Tocopherol
Brand: TargetMol
SKU: TMA2394
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TMA2394Cas No. 10191-41-0

Alias Ephanyl, DL-α-Tocopherol, Alpha-Tochopherol

DL-alpha-Tocopherol (Ephanyl) is a synthetic vitamin E that protects skin fibroblasts from the cytotoxic effects of UV light and has antioxidant properties.

DL-alpha-Tocopherol

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Purity: 99.90%

Catalog No. TMA2394Alias Ephanyl, DL-α-Tocopherol, Alpha-TochopherolCas No. 10191-41-0

DL-alpha-Tocopherol (Ephanyl) is a synthetic vitamin E that protects skin fibroblasts from the cytotoxic effects of UV light and has antioxidant properties.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.90%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

DL-alpha-Tocopherol AI Summary

DL-alpha-Tocopherol demonstrates multifaceted bioactivity across several assays. It exhibits significant antioxidant properties, highlighted by its ability to scavenge DPPH free radicals with an EC50 of 19900.0 nM, and inhibits various forms of lipid peroxidation in rat brain homogenate and microsomes with IC50 values of 14000.0 nM, 273000.0 nM, and 35700.0 nM. Furthermore, in different cell assays, it shows efficacy in inhibiting tau fibril formation (IC50 of 5011.9 nM), Polymerase Kappa and USP1/UAF1 (IC50 ranging from 11220.2 nM to 14125.4 nM), and displays antiviral activity against Foot and Mouth Disease Virus (IC50 of 12589.3 nM). The compound also affects cell viability with IC50 values around 20000.0 nM for various colorectal cancer cell lines, except for an IC50 of 2614.7 nM in RKO cells. Additionally, it shows a moderate inhibition on gamma-secretase presenilin-1 without significantly impacting amyloid beta 42 and beta 40, but promoting amyloid beta 38 generation at an EC50 greater than 100000.0 nM. In sodium fluorescein uptake assays, it inhibits OATP1B1 and OATP1B3 transport with rates of 85.48% and 84.17% respectively. Lastly, it inhibits porcine heart malate dehydrogenase with an IC50 of 79.0 nM and reduces enzyme activity by 69.0%. These diverse activities suggest potential therapeutic applications for DL-alpha-Tocopherol in antioxidant, neuronal, antiviral, and cancer research contexts..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DL-alpha-Tocopherol (Ephanyl) is a synthetic vitamin E that protects skin fibroblasts from the cytotoxic effects of UV light and has antioxidant properties.
Synonyms	Ephanyl, DL-α-Tocopherol, Alpha-Tochopherol

Chemical Properties

Molecular Weight	430.71
Formula	C₂₉H₅₀O₂
Cas No.	10191-41-0
Smiles	CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCC2=C(C)C(O)=C(C)C(C)=C2O1
Relative Density.	0.95. Temperature:25 °C.

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (58.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3217 mL	11.6087 mL	23.2175 mL	116.0874 mL
5 mM	0.4643 mL	2.3217 mL	4.6435 mL	23.2175 mL
10 mM	0.2322 mL	1.1609 mL	2.3217 mL	11.6087 mL
20 mM	0.1161 mL	0.5804 mL	1.1609 mL	5.8044 mL
50 mM	0.0464 mL	0.2322 mL	0.4643 mL	2.3217 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc