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BRD4 Inhibitor-38 (Compound 25) is an orally active BRD4 inhibitor, exhibiting IC50 values of 3.64 μM for BRD4 BD1 and 0.12 μM for BRD4 BD2. It also demonstrates anti-inflammatory properties, with an IC50 value of 1.98 μM for nitric oxide (NO) production.
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50 mg | Inquiry | Backorder |
Description | BRD4 Inhibitor-38 (Compound 25) is an orally active BRD4 inhibitor, exhibiting IC50 values of 3.64 μM for BRD4 BD1 and 0.12 μM for BRD4 BD2. It also demonstrates anti-inflammatory properties, with an IC50 value of 1.98 μM for nitric oxide (NO) production. |
Targets&IC50 | BRD4 BD2:0.12 μM |
In vitro | BRD4 Inhibitor-38 (Compound 25) exhibits anti-inflammatory activity in Raw 264.7 and THP-1 cells when used at concentrations ranging from 2.5 to 20 μM over a 2-hour period [1]. |
In vivo | BRD4 Inhibitor-38 (Compound 25) demonstrates anti-inflammatory activity in a mouse model of acute inflammation induced by LPS (10 mg/kg; single dose) when administered orally in doses ranging from 25 to 100 mg/kg [1]. |
Molecular Weight | 338.357 |
Formula | C19H18N2O4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
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