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Bendazac

Name: Bendazac
Brand: TargetMol
SKU: T7807
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7807Cas No. 20187-55-7

Alias Bendazolic acid, AF-983

Bendazac (Bendazolic acid) is an anticataract drug. It may act by preventing protein denaturation.

Bendazac

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Purity: 97.06%

Catalog No. T7807Alias Bendazolic acid, AF-983Cas No. 20187-55-7

Bendazac (Bendazolic acid) is an anticataract drug. It may act by preventing protein denaturation.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	In Stock	In Stock
500 mg	$53	In Stock	In Stock
1 g	$77	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.06%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bendazac (Bendazolic acid) is an anticataract drug. It may act by preventing protein denaturation.
In vitro	Bendazac (bendazac L-lysine and sodium) inhibits the early stages of protein glycation, as well as the formation of fluorescent advanced glycation products.?Bendazac lysine (20 mM) proved to be more effective in inhibiting fluorescence development (67% inhibition) that the corresponding sodium salt (35% inhibition).?No significant differences were found with respect to furosine levels ;?about 40% inhibition was produced with either bendazac lysine or sodium salt bendazac clearly inhibits glycation of human lens crystallins, as can be efficiently monitored by following specific changes in lens protein fluorescence[1]
Synonyms	Bendazolic acid, AF-983

Chemical Properties

Molecular Weight	282.29
Formula	C₁₆H₁₄N₂O₃
Cas No.	20187-55-7
Smiles	C(N1C=2C(C(OCC(O)=O)=N1)=CC=CC2)C3=CC=CC=C3
Relative Density.	1.1658 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (212.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5425 mL	17.7123 mL	35.4246 mL	177.1228 mL
5 mM	0.7085 mL	3.5425 mL	7.0849 mL	35.4246 mL
10 mM	0.3542 mL	1.7712 mL	3.5425 mL	17.7123 mL
20 mM	0.1771 mL	0.8856 mL	1.7712 mL	8.8561 mL
50 mM	0.0708 mL	0.3542 mL	0.7085 mL	3.5425 mL
100 mM	0.0354 mL	0.1771 mL	0.3542 mL	1.7712 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc