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Yangambin

Name: Yangambin
Brand: TargetMol
SKU: TN2322
Price: 126 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2322Cas No. 13060-14-5

Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibition the Ca2+ influx through voltage-gated Ca2+ channels. Yangambin also has central nervous system activity.

Yangambin

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Purity: 98.02%

Catalog No. TN2322Cas No. 13060-14-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$126	In Stock	In Stock
5 mg	$313	In Stock	-
10 mg	$496	In Stock	-
25 mg	$793	In Stock	-
50 mg	$1,070	In Stock	-
1 mL x 10 mM (in DMSO)	$242	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.02%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Yangambin AI Summary

Yangambin inhibits the 12-O-tetradecanoylphorbol 13-acetate-induced transformation of mouse JB6 cells in a soft agar assay with an IC50 value greater than 4.0 µg/mL. It also inhibits nitric oxide production in LPS-stimulated mouse BV2 cells, showing an IC50 value of 28600.0 nM. Additionally, Yangambin increases 2-NBDG uptake in mouse 3T3L1 cells at 400 µg/mL (Fold Change = 1.45) and inhibits PTP1B with an IC50 value of 16820.0 nM. Notably, it exhibits strong inhibitory activity against acetylcholinesterase with an IC50 value of 616.0 nM and 65.0% inhibition at concentrations ranging from 0.01 to 100 µM, highlighting its potential as a potent enzyme inhibitor targeting acetylcholinesterase..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	446.49
Formula	C₂₄H₃₀O₈
Cas No.	13060-14-5
Smiles	[H][C@]12CO[C@H](c3cc(OC)c(OC)c(OC)c3)[C@@]1([H])CO[C@@H]2c1cc(OC)c(OC)c(OC)c1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (134.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2397 mL	11.1985 mL	22.3969 mL	111.9846 mL
5 mM	0.4479 mL	2.2397 mL	4.4794 mL	22.3969 mL
10 mM	0.2240 mL	1.1198 mL	2.2397 mL	11.1985 mL
20 mM	0.1120 mL	0.5599 mL	1.1198 mL	5.5992 mL
50 mM	0.0448 mL	0.2240 mL	0.4479 mL	2.2397 mL
100 mM	0.0224 mL	0.1120 mL	0.2240 mL	1.1198 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc