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Withanolide A

🥰Excellent
Catalog No. TN2309Cas No. 32911-62-9

Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.

Withanolide A

Withanolide A

🥰Excellent
Purity: 99.5%
Catalog No. TN2309Cas No. 32911-62-9
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$99In StockIn Stock
5 mg$245In StockIn Stock
10 mg$375In StockIn Stock
25 mg$597In StockIn Stock
50 mg$885-In Stock
1 mL x 10 mM (in DMSO)$392In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.5%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
In vitro
A quantitative structure activity relationship (QSAR) model was developed by a forward stepwise multiple linear regression method to predict the activity of Withanolide Analogs against human breast cancer. The most effective QSAR model for anticancer activity against the SK-Br-3 cell showed the best correlation with activity (r2=0.93 and rCV2 =0.90). Similarly, cross-validation regression coefficient (rCV2=0.85) of the best QSAR model against the MCF7/BUS cells showed a high correlation (r2=0.91). In particular, compounds CID 73621, CID 435144, CID 301751 and CID 3372729 have a marked antiproliferative activity against the MCF7/BUS cells, while 2,3-dihydrowithaferin A-3-beta-O-sulfate, withanolide 5, Withanolide A, withaferin A, CID 10413139, CID 11294368, CID 53477765, CID 135887, CID 301751 and CID 3372729 have a high activity against the Sk-Br-3 cells compared to standard drugs 5-fluorouracil (5-FU) and camptothecin[1]
Chemical Properties
Molecular Weight470.6
FormulaC28H38O6
Cas No.32911-62-9
Smiles[H][C@@]12CC[C@H]([C@@](C)(O)[C@@]3([H])CC(C)=C(C)C(=O)O3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@H]2O[C@@H]2[C@@]2(O)CC=CC(=O)[C@]12C
Relative Density.1.264 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (116.87 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 1.67 mg/mL (3.55 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1249 mL10.6247 mL21.2495 mL106.2473 mL
5 mM0.4250 mL2.1249 mL4.2499 mL21.2495 mL
10 mM0.2125 mL1.0625 mL2.1249 mL10.6247 mL
20 mM0.1062 mL0.5312 mL1.0625 mL5.3124 mL
50 mM0.0425 mL0.2125 mL0.4250 mL2.1249 mL
100 mM0.0212 mL0.1062 mL0.2125 mL1.0625 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

Withanolide ATNF-αNF-κBNFκBNF-kBNFkBInhibitorinhibitEGFR
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