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Withanolide A

🥰Excellent
Catalog No. TN2309Cas No. 32911-62-9

Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.

Withanolide A

Withanolide A

🥰Excellent
Purity: 99.5%
Catalog No. TN2309Cas No. 32911-62-9
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$99In StockIn Stock
5 mg$245In StockIn Stock
10 mg$375In StockIn Stock
25 mg$597In StockIn Stock
50 mg$885-In Stock
1 mL x 10 mM (in DMSO)$392In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.5%
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Product Introduction

Bioactivity
Description
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
In vitro
A quantitative structure activity relationship (QSAR) model was developed by a forward stepwise multiple linear regression method to predict the activity of Withanolide Analogs against human breast cancer. The most effective QSAR model for anticancer activity against the SK-Br-3 cell showed the best correlation with activity (r2=0.93 and rCV2 =0.90). Similarly, cross-validation regression coefficient (rCV2=0.85) of the best QSAR model against the MCF7/BUS cells showed a high correlation (r2=0.91). In particular, compounds CID 73621, CID 435144, CID 301751 and CID 3372729 have a marked antiproliferative activity against the MCF7/BUS cells, while 2,3-dihydrowithaferin A-3-beta-O-sulfate, withanolide 5, Withanolide A, withaferin A, CID 10413139, CID 11294368, CID 53477765, CID 135887, CID 301751 and CID 3372729 have a high activity against the Sk-Br-3 cells compared to standard drugs 5-fluorouracil (5-FU) and camptothecin[1]
Chemical Properties
Molecular Weight470.6
FormulaC28H38O6
Cas No.32911-62-9
Smiles[H][C@@]12CC[C@H]([C@@](C)(O)[C@@]3([H])CC(C)=C(C)C(=O)O3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@H]2O[C@@H]2[C@@]2(O)CC=CC(=O)[C@]12C
Relative Density.1.264 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (116.87 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1249 mL10.6247 mL21.2495 mL106.2473 mL
5 mM0.4250 mL2.1249 mL4.2499 mL21.2495 mL
10 mM0.2125 mL1.0625 mL2.1249 mL10.6247 mL
20 mM0.1062 mL0.5312 mL1.0625 mL5.3124 mL
50 mM0.0425 mL0.2125 mL0.4250 mL2.1249 mL
100 mM0.0212 mL0.1062 mL0.2125 mL1.0625 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

Withanolide ATNF-αNF-κBNFκBNF-kBNFkBInhibitorinhibitEGFR
Related Tags: buy Withanolide A | purchase Withanolide A | Withanolide A cost | order Withanolide A | Withanolide A chemical structure | Withanolide A in vitro | Withanolide A formula | Withanolide A molecular weight
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