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L-Serine
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Catalog No. T2O2730Cas No. 56-45-1
Alias serine, (S)-Serine, (S)-2-Amino-3-hydroxypropanoic acid, (-)-Serine
L-Serine (serine) is a non-essential amino acid in humans, L-Serine is present and functionally important in many proteins.L-Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin.
L-Serine
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Purity: 99.31%
Catalog No. T2O2730Alias serine, (S)-Serine, (S)-2-Amino-3-hydroxypropanoic acid, (-)-SerineCas No. 56-45-1
L-Serine (serine) is a non-essential amino acid in humans, L-Serine is present and functionally important in many proteins.L-Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 g | $31 | In Stock | In Stock | |
| 5 g | $70 | - | In Stock | |
| 10 g | $98 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.31%
Appearance:Solid
Color:White
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Product Introduction
L-Serine AI Summary
L-Serine has a measured partition coefficient (logP) value of 3.3, indicating moderate lipophilicity, which affects its solubility, permeability, bioavailability, and distribution in the body. It demonstrates a broad range of bioactivities, including:
1. Inhibition of several enzymes and receptors:
- Human Jumonji Domain Containing 2E (JMJD2E) with a potency of 39810.7 nM.
- Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) with potencies of 100000.0 nM and 63095.7 nM in different assays.
- Anthrax Lethal Toxin Internalization with a potency of 1000.0 nM.
- Acetylcholine Muscarinic M1 Receptor with potencies of 11.2 nM and 19952.6 nM in different assays.
- Polymerase Kappa with a potency of 354.8 nM.
- Marburg Virus binding or entry into cells with a potency of 14125.4 nM.
2. Selective inhibition towards Setaria cervi Gamma-glutamyltranspeptidase compared to Wistar rat Gamma-glutamyltranspeptidase, with a Ki value of 400000.0 nM for Setaria and 50000.0 nM for Wistar.
3. Potent inhibitory activity against butyrylcholinesterase and acetylcholinesterase enzymes, with IC50 values of 16.0 nM and 15.0 nM, respectively.
4. Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells with a Ki value of 35000000.0 nM.
5. Bioactivity related to the inhibition of amino acid transporters ASCT1 and ASCT2, with varying IC50 values indicating its potency in different assay conditions, as well as effects on asc-1 mediated [3H]-D-serine uptake in rat forebrain synaptosomes.
6. Binding affinity to the Pyrococcus horikoshii sodium-coupled aspartate transporter with a Kd value of 160,000.0 nM.
7. No significant bioactivity observed in some assays with AC50 values >30,000.0 nM.
8. Activation of PKM2 with an EC50 value of 1300000.0 nM.
Overall, L-Serine exhibits considerable activity across a diverse range of biological targets, suggesting potential as a modulator in various biochemical pathways..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-Serine (serine) is a non-essential amino acid in humans, L-Serine is present and functionally important in many proteins.L-Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. |
| Synonyms | serine, (S)-Serine, (S)-2-Amino-3-hydroxypropanoic acid, (-)-Serine |
| Molecular Weight | 105.09 |
| Formula | C3H7NO3 |
| Cas No. | 56-45-1 |
| Smiles | N[C@@H](CO)C(O)=O |
| Relative Density. | 1.6 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 128.75 mg/mL (1225.14 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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