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Anti-NOTCH3 Antibody (7P604)
😃Good
Catalog No. TMAB-09571
Anti-NOTCH3 Antibody (7P604) is a Mouse antibody targeting NOTCH3. Anti-NOTCH3 Antibody (7P604) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-NOTCH3 Antibody (7P604)
Anti-NOTCH3 Antibody (7P604)
😃Good
Catalog No. TMAB-09571
Anti-NOTCH3 Antibody (7P604) is a Mouse antibody targeting NOTCH3. Anti-NOTCH3 Antibody (7P604) can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $295 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-NOTCH3 Antibody (7P604) is a Mouse antibody targeting NOTCH3. Anti-NOTCH3 Antibody (7P604) can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 7P604 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:200-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Notch 3 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus. |
| Tissue Specificity | Ubiquitously expressed in fetal and adult tissues. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human NOTCH3 |
| Antigen Species | Human |
| Gene Name | NOTCH3 |
| Gene ID | |
| Protein Name | Neurogenic locus notch homolog protein 3 |
| Uniprot ID | |
| Function | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. |
| Molecular Weight | Theoretical: 255 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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