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DPTIP

🥰Excellent
Catalog No. T60043Cas No. 351353-48-5

DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.

DPTIP
Other Forms of DPTIP:
DPTIP hydrochlorideT2033102361799-64-4
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DPTIP

🥰Excellent
Purity: 99.88%
Catalog No. T60043Cas No. 351353-48-5
DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$41In StockIn Stock
2 mg$57In StockIn Stock
5 mg$97In StockIn Stock
10 mg$155In StockIn Stock
25 mg$313In StockIn Stock
50 mg$513In StockIn Stock
100 mg$747-In Stock
1 mL x 10 mM (in DMSO)$97In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.88%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.
In vitro
DPTIP (30 μM) decreases exosome release by 50% in astrocytes. DPTIP(0.03-30 μM) dose-dependently blocks EV secretion[1].
In vivo
In mice, DPTIP potently (10 mg/kg; i.p.) inhibits IL-1β-induced astrocyte-derived EV release. Brain concentrations of DPTIP are above its IC50 for neutral sphingomyelinase 2 inhibition for at least 4 h after the administration of DPTIP[2].
Chemical Properties
Molecular Weight378.44
FormulaC21H18N2O3S
Cas No.351353-48-5
SmilesCOc1cc(cc(OC)c1O)-c1nc(c([nH]1)-c1cccs1)-c1ccccc1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 245 mg/mL (647.39 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6424 mL13.2121 mL26.4243 mL132.1213 mL
5 mM0.5285 mL2.6424 mL5.2849 mL26.4243 mL
10 mM0.2642 mL1.3212 mL2.6424 mL13.2121 mL
20 mM0.1321 mL0.6606 mL1.3212 mL6.6061 mL
50 mM0.0528 mL0.2642 mL0.5285 mL2.6424 mL
100 mM0.0264 mL0.1321 mL0.2642 mL1.3212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

vesiclesPhospholipaseN-SMaseneutral sphingomyelinaseInhibitorinhibitextracellularexosomeDPTIP
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