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Pregnenolone Carbonitrile

🥰Excellent
Catalog No. T21818Cas No. 1434-54-4
Alias Pregnenolone 16α-carbonitrile , 5-Pregnen-3β-ol-20-one-16α-carbonitrile

Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.

Pregnenolone Carbonitrile

Pregnenolone Carbonitrile

🥰Excellent
Purity: 99.69%
Catalog No. T21818Alias Pregnenolone 16α-carbonitrile , 5-Pregnen-3β-ol-20-one-16α-carbonitrileCas No. 1434-54-4
Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$49In StockIn Stock
1 mL x 10 mM (in DMSO)$44-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.69%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.
In vitro
Pregnenolone Carbonitrile is hepatoprotective by increasing resistance to subsequent stressful insults[4].
In vivo
In WT mice, Pregnenolone Carbonitrile (40 mg/kg/day; i.p.) induces the expression of CYP3A11 and CYP2B10 at the mRNA, protein, and enzymatic levels[2]. In adult female Sprague-Dawley rats, Pregnenolone Carbonitrile (100 mg/kg; i.p.) induces the expression of CYP3A mRNA[3]. In male Sprague-Dawley rats, Pregnenolone Carbonitrile (35 mg/kg; gavage) increase in Pgp expression[4].
SynonymsPregnenolone 16α-carbonitrile , 5-Pregnen-3β-ol-20-one-16α-carbonitrile
Chemical Properties
Molecular Weight341.49
FormulaC22H31NO2
Cas No.1434-54-4
Smiles[H][C@@]12C[C@@H](C#N)[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
Relative Density.1.13 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (87.85 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9283 mL14.6417 mL29.2834 mL146.4172 mL
5 mM0.5857 mL2.9283 mL5.8567 mL29.2834 mL
10 mM0.2928 mL1.4642 mL2.9283 mL14.6417 mL
20 mM0.1464 mL0.7321 mL1.4642 mL7.3209 mL
50 mM0.0586 mL0.2928 mL0.5857 mL2.9283 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

PXRPregnenolone CarbonitrilePregnenolone 16α-carbonitrilePregnenolone 16alpha-carbonitrilePregnenolone 16a-carbonitrileP4503AorallyInhibitorinhibitCytochrome P450cytochromeCYPsCYP3A5-Pregnen-3b-ol-20-one-16a-carbonitrile5-Pregnen-3beta-ol-20-one-16alpha-carbonitrile
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