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Baccatin III

Name: Baccatin III
Brand: TargetMol
SKU: T2788
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2788Cas No. 27548-93-2

Alias Baccatin Ⅲ

Baccatin III (Baccatin Ⅲ) is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It has immunomodulatory and anticancer chemotherapeutic activities.

Baccatin III

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Purity: 98.45%

Catalog No. T2788Alias Baccatin ⅢCas No. 27548-93-2

Baccatin III (Baccatin Ⅲ) is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It has immunomodulatory and anticancer chemotherapeutic activities.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	-
5 mg	$44	In Stock	-
10 mg	$77	In Stock	-
1 mL x 10 mM (in DMSO)	$56	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.45%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Baccatin III AI Summary

Baccatin III demonstrates a range of bioactivities that include tubulin and microtubule interaction, with moderate stimulation of tubulin assembly and low cytotoxicity against B16 melanoma cell lines, and potentially a distinct mechanism of action from taxol. It shows inhibitory effects in P388 leukemia cells (IC50=63095734.45 nM) and modulates Vincristine accumulation in multidrug-resistant human ovarian cancer cells. It also exhibits cytotoxicity against murine Leukemia L1210, Epidermoid Carcinoma KB, VA13, HepG2, and WI38 cells, alongside a range of human cell lines (IC50 values 7400.0 nM to 24000.0 nM). Moreover, Baccatin III acts as an acetylcholinesterase (AChE) inhibitor (27.77% inhibition at 2 mg/ml) and displays limited butyrylcholinesterase (BChE) inhibitory activity (5.3% inhibition). It also reduces viability in human HL cells by 34.6% at 50 uM over 72 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Baccatin III (Baccatin Ⅲ) is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It has immunomodulatory and anticancer chemotherapeutic activities.
Synonyms	Baccatin Ⅲ

Chemical Properties

Molecular Weight	586.63
Formula	C₃₁H₃₈O₁₁
Cas No.	27548-93-2
Smiles	O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](O)C5)[H]
Relative Density.	1.2062 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (93.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7047 mL	8.5233 mL	17.0465 mL	85.2326 mL
5 mM	0.3409 mL	1.7047 mL	3.4093 mL	17.0465 mL
10 mM	0.1705 mL	0.8523 mL	1.7047 mL	8.5233 mL
20 mM	0.0852 mL	0.4262 mL	0.8523 mL	4.2616 mL
50 mM	0.0341 mL	0.1705 mL	0.3409 mL	1.7047 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc