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Anti-HEXDC Polyclonal Antibody

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Catalog No. TMAB-06998

Anti-HEXDC Polyclonal Antibody is a Rabbit antibody targeting HEXDC. Anti-HEXDC Polyclonal Antibody can be used in WB.

Anti-HEXDC Polyclonal Antibody

Anti-HEXDC Polyclonal Antibody

Copy Product Info
😃Good
Catalog No. TMAB-06998
Anti-HEXDC Polyclonal Antibody is a Rabbit antibody targeting HEXDC. Anti-HEXDC Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5297-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-HEXDC Polyclonal Antibody is a Rabbit antibody targeting HEXDC. Anti-HEXDC Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Dog,Horse)
Verified Activity
1. Sample: A549 (Human) Cell Lysate at 40 μg
Primary: Anti-HEXDC (TMAB-06998) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 54 kD
Observed band size: 48 kD
2. Sample: HepG2 (Human) Cell Lysate at 40 μg
Primary: Anti-HEXDC (TMAB-06998) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 54 kD
Observed band size: 48 kD
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasmic and Nuclear
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundHEXDC, also known as hexosaminidase D, beta-hexosaminidase D, N-acetyl-beta-galactosaminidase, hexosaminidase domain-containing protein or beta-N-acetylhexosaminidase, is a 486 amino acid cytoplasmic and nuclear protein that has hexosaminidase activity and belongs to the glycosyl hydrolase 20 family. Existing as two alternatively spliced isoforms, HEXDC catalyzes the hydrolysis of non-reducing N-acetyl-D-hexosamine residues near the termini of N-acetyl-beta-D-hexosaminides. The gene encoding HEXDC maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Defects in p53 is associated with malignant cell growth and Li-Fraumeni syndrome. BRCA1 is directly involved in DNA repair and is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human HEXDC
Antigen Species
Human
Gene Name
HEXD
Gene ID
284004
Protein Name
Hexosaminidase D
Uniprot ID
Q8WVB3
Function
Has hexosaminidase activity.
Chemical Properties
Molecular WeightTheoretical: 54 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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