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Anti-Dystrophin Antibody (8T703)
😃Good
Catalog No. TMAB-05374
Anti-Dystrophin Antibody (8T703) is a Rabbit antibody targeting Dystrophin. Anti-Dystrophin Antibody (8T703) can be used in IHC-P,IF,IHC-Fr.
Anti-Dystrophin Antibody (8T703)
Anti-Dystrophin Antibody (8T703)
😃Good
Catalog No. TMAB-05374
Anti-Dystrophin Antibody (8T703) is a Rabbit antibody targeting Dystrophin. Anti-Dystrophin Antibody (8T703) can be used in IHC-P,IF,IHC-Fr.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Dystrophin Antibody (8T703) is a Rabbit antibody targeting Dystrophin. Anti-Dystrophin Antibody (8T703) can be used in IHC-P,IF,IHC-Fr. |
| Ig Type | IgG |
| Clone | 8T703 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | IHC-P: 1:50-200; IF: 1:50-200; IHC-Fr: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; sarcolemma. Cytoplasm; cytoskeleton. |
| Tissue Specificity | Expressed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma. Expressed in brain, muscle, kidney, lung and testis. Isoform 5 is expressed in heart, brain, liver, testis and hepatoma cells. Most tissues contain transcripts of multiple isoforms, however only isoform 5 is detected in heart and liver. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [provided by RefSeq, Dec 2016] |
| Immunogen | A synthesized peptide: human Dystrophin |
| Antigen Species | Human |
| Gene Name | DMD |
| Gene ID | |
| Protein Name | Dystrophin |
| Uniprot ID | |
| Function | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. |
| Molecular Weight | Theoretical: 405 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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