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Isolinderalactone

Name: Isolinderalactone
Brand: TargetMol
SKU: T8213
Rating: 4.5 (1 reviews)

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Catalog No. T8213Cas No. 957-66-4

Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.

Isolinderalactone

😃Good

Catalog No. T8213Cas No. 957-66-4

Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.

Pack Size	Price	Availability
1 mg	$71	Backorder
5 mg	$172	Backorder
10 mg	$286	Backorder
25 mg	$483	Backorder
50 mg	$693	Backorder
100 mg	$962	Backorder
200 mg	$1,290	Backorder
1 mL x 10 mM (in DMSO)	$159	In Stock

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Product Introduction

Bioactivity

Description	Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
Targets&IC50	iNOS:0.30 uM
In vitro	Isolinderalactone induces apoptosis in MDA-MB-231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c, may become a novel treatment for triple-negative breast cancer in the future.

Chemical Properties

Molecular Weight	244.29
Formula	C₁₅H₁₆O₃
Cas No.	957-66-4
Smiles	[H][C@@]12OC(=O)C(=C)[C@]1([H])[C@](C)(Cc1occ(C)c21)C=C
Relative Density.	1.16 g/cm3 at 20℃
Color	White
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (92.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0935 mL	20.4675 mL	40.9350 mL	204.6748 mL
5 mM	0.8187 mL	4.0935 mL	8.1870 mL	40.9350 mL
10 mM	0.4093 mL	2.0467 mL	4.0935 mL	20.4675 mL
20 mM	0.2047 mL	1.0234 mL	2.0467 mL	10.2337 mL
50 mM	0.0819 mL	0.4093 mL	0.8187 mL	4.0935 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc