Anti-CPV VP2 Antibody (3D582) is a Mouse antibody targeting CPV VP2. Anti-CPV VP2 Antibody (3D582) can be used in WB,ELISA.

IgG

3D582

CPV

WB: 1:500-2000; ELISA: 1:5000-10000

Monoclonal

Recombinant Protein: Canine parvovirus Capsid protein VP2

CPV-2

Capsid protein VP2

Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptor TFRC. This attachment induces virion internalization predominantly through clathrin-endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell. Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein. Exposure of nuclear localization signal probably allows nuclear import of capsids.