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Poliumoside

Name: Poliumoside
Brand: TargetMol
SKU: T6S2384
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S2384Cas No. 94079-81-9

Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibitory effects on rat lens aldose reductase with IC50 values of 0.85 μM.Poliumoside has oxidant scavenging, antibacterial and hemostasis capacities, it can inhibit Biofilm-forming Staphylococcus aureus in mice.

Poliumoside

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Purity: 99.80%

Catalog No. T6S2384Cas No. 94079-81-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
2 mg	$43	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$119	In Stock	In Stock
25 mg	$257	In Stock	In Stock
50 mg	$418	In Stock	In Stock
100 mg	$679	-	In Stock
200 mg	$945	-	In Stock
1 mL x 10 mM (in DMSO)	$132	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.80%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Poliumoside AI Summary

Poliumoside inhibits human recombinant PKCalpha with an IC50 value of 24400.0 nM and exhibits antifungal activity. It has a minimum inhibitory concentration (MIC) greater than 125.0 µg/mL against Candida parapsilosis and Candida albicans, and an MIC of 62.5 µg/mL against Cryptococcus neoformans after 48 hours, as determined by the microbroth dilution method..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibitory effects on rat lens aldose reductase with IC50 values of 0.85 μM.Poliumoside has oxidant scavenging, antibacterial and hemostasis capacities, it can inhibit Biofilm-forming Staphylococcus aureus in mice.
Targets&IC50	Aldose reductase (rat lens):0.85 μM

Chemical Properties

Molecular Weight	770.73
Formula	C₃₅H₄₆O₁₉
Cas No.	94079-81-9
Smiles	CC1OC(OCC2OC(OCCc3ccc(O)c(O)c3)C(O)C(OC3OC(C)C(O)C(O)C3O)C2OC(=O)\C=C\c2ccc(O)c(O)c2)C(O)C(O)C1O
Relative Density.	1.62g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 262 mg/mL (339.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2975 mL	6.4874 mL	12.9747 mL	64.8736 mL
5 mM	0.2595 mL	1.2975 mL	2.5949 mL	12.9747 mL
10 mM	0.1297 mL	0.6487 mL	1.2975 mL	6.4874 mL
20 mM	0.0649 mL	0.3244 mL	0.6487 mL	3.2437 mL
50 mM	0.0259 mL	0.1297 mL	0.2595 mL	1.2975 mL
100 mM	0.0130 mL	0.0649 mL	0.1297 mL	0.6487 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc