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Gentisein
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Catalog No. T19931Cas No. 529-49-7
Alias NSC-329491, NSC329491, NSC 329491
Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7 µM[1][2].
Gentisein
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Purity: 96.89%
Catalog No. T19931Alias NSC-329491, NSC329491, NSC 329491Cas No. 529-49-7
Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7 µM[1][2].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $40 | In Stock | In Stock | |
| 10 mg | $56 | In Stock | In Stock | |
| 25 mg | $113 | In Stock | In Stock | |
| 50 mg | $185 | In Stock | In Stock | |
| 100 mg | $273 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:96.89%
Appearance:Solid
Color:White
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Product Introduction
Gentisein AI Summary
Gentisein exhibits a diverse range of bioactivities. It inhibits monoamine oxidase activity with an IC50 value of 8000.0 nM. Additionally, it acts as an inhibitor of yeast alpha-glucosidase, with IC50 values ranging from 14700.0 nM to 67608297.54 nM, suggesting varying inhibitory potencies. Gentisein also inhibits the FAS enzyme, with an IC50 value of 40980.0 nM.
In terms of antibacterial activity, the compound is effective against Staphylococcus aureus and Moraxella catarrhalis with a MIC of 128.0 µg/mL, but it shows no significant activity against other bacteria such as Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Escherichia coli. It displays low cytotoxicity towards human HepG2 cells and human Jurkat T cells, with IC50 values exceeding 100000.0 nM.
Against influenza A virus neuraminidase, Gentisein presents IC50 values ranging from 9.14 to 26.81 µg/mL and demonstrates a high selectivity ratio for the oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant.
The compound exhibits cytotoxic properties in various cancer cell lines, albeit with varying degrees of potency. For instance, it shows IC50 values of 192660.0 nM in MCF7/ADR cells, 146350.0 nM in Taxol-resistant A549 cells, and 38520.0 nM in Taxol-resistant SMMC7721 cells. Additionally, it demonstrates antiproliferative activity in MDA-MB-231 and K562 cells with IC50 values of 25100 nM and 105600 nM respectively, while having a less pronounced effect on HepG2 and COLO320 cells with IC50 values exceeding 200000 nM.
However, Gentisein shows no significant growth inhibition in human MCF7, HeLaS3, KB, HepG2, and HT-29 cells after 72 hours of incubation (IC50 > 10000.0 nM). It does exhibit cytotoxicity against HepG2 cells with an IC50 of 18300.0 nM determined after 48 hours of incubation.
Overall, Gentisein has potential applications in treating conditions related to carbohydrate metabolism due to its inhibitory activity against alpha-glucosidase from various sources, with IC50 values ranging from 3.2 µg/mL to 31800.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7 µM[1][2]. |
| Synonyms | NSC-329491, NSC329491, NSC 329491 |
| Molecular Weight | 244.2 |
| Formula | C13H8O5 |
| Cas No. | 529-49-7 |
| Smiles | Oc1ccc2oc3cc(O)cc(O)c3c(=O)c2c1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (92.14 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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