Immuno-Oncology Compound Library

Catalog No. L2170

Library Compound List Excel SDF

Traditional cancer therapies include surgery, radiation therapy, and chemotherapy. With the rapid development of science and technology in medicine, new cancer therapies such as immunotherapy, targeted therapy, radiofrequency ablation for cancer are actively developed to help patients fight cancer. Cancer immunotherapy, also known as immuno-oncology, is a form of cancer treatment that uses the power of the body’s own immune system to prevent, control, and eliminate cancer. Science magazine—America’s leading scientific journal—has deemed cancer immunotherapy the 2013 “Breakthrough of the Year,” beating out nine other contenders.

There are several types of immunotherapy, including: Non-specific immunotherapies, CAR T-cell therapy, cancer vaccines, checkpoint inhibitors, etc. Most cancer immunotherapy agents being developed or approved are engineered T cells targeting tumors or mostly antibody-based biologics that target the immune checkpoint cascade. The success of these biologics in the clinic is now inspiring the discovery and development of small molecules that act on intracellular targets affecting immuno-modulatory pathways in cancer. Small molecule agents as opposed to biologics that steer or enable the immune system to attack cancer cells, represent an emerging area of R&D focus in the oncology drug development industry. Small molecules are being investigated as stand-alone agents and synergistically with approved biologics because of the ability of small molecules to reach intracellular targets and the greater patient convenience offered by their oral bioavailability. The foundation for the pursuit of small molecule immune therapies for cancer is the wide spectrum of cells and their molecular pathways that are used by the immune system to suppress or enhance cellular immunity. Such novel immunotherapeutic approaches can either negate immune suppression in the tumor milieu or facilitate cytolytic lymphocyte responses to the tumor.

TargetMol’s Immuno-Oncology Compound Library carefully collects 454 bioactive compounds targeting intracellular pathways modulating the innate and adaptive immune response is a powerful tool for your research and drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

Request for Quote

If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

Request Library

Product Description

A unique collection of 454 compounds acting on immune-oncology therapeutic targets can be used for high throughput and high content screening；
Targets include PD-1/PD-L1, HER2, STAT3, CTLA4, IDO, STING, CCR, CXCR, TLR, etc.
Detailed compound information with structure, target, and biological activity description；
NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

See More... Hide

Library Composition

TNF (78)

Apoptosis (60)

PI3K (56)

Autophagy (47)

STAT (46)

TLR (45)

CCR (38)

CXCR (27)

NF-κB (24)

TGF-beta/Smad (24)

IL Receptor (24)

EGFR (23)

Indoleamine 2,3-Dioxygenase (IDO) (22)

STING (19)

HER (18)

mTOR (17)

Adenosine Receptor (17)

HIV Protease (16)

Endogenous Metabolite (14)

Antibacterial (14)

PD-1/PD-L1 (14)

BTK (13)

Interleukin (13)

COX (13)

ALK (13)

RIP kinase (12)

JAK (11)

VEGFR (10)

IDO (10)

Epigenetic Reader Domain (9)

p38 MAPK (8)

c-Fms (8)

Parasite (8)

DNA-PK (7)

Antibiotic (7)

CSF-1R (7)

Reactive Oxygen Species (6)

PDGFR (6)

FLT (6)

NO Synthase (6)

Src (6)

MMP (5)

Influenza Virus (5)

c-Kit (5)

ERK (5)

Arginase (5)

IFNAR (4)

Akt (4)

Raf (4)

c-Met/HGFR (4)

PDE (4)

SARS-CoV (4)

Virus Protease (4)

Casein Kinase (3)

Molecular Glues (3)

HDAC (3)

Ferroptosis (3)

5-HT Receptor (3)

FGFR (3)

HCV Protease (3)

NOD (3)

Tyrosinase (3)

Ligand for E3 Ligase (3)

P-gp (3)

ROS (2)

Wnt/beta-catenin (2)

AChE (2)

Antiviral (2)

CDK (2)

HSP (2)

Bcr-Abl (2)

PPAR (2)

Topoisomerase (2)

IκB/IKK (2)

PI4K (2)

Antioxidant (2)

AMPK (2)

P450 (2)

MEK (2)

Potassium Channel (2)

Caspase (2)

HIF/HIF Prolyl-Hydroxylase (2)

NOD-like Receptor (NLR) (2)

Carbonic Anhydrase (2)

NOS (2)

Drug Metabolite (2)

Nrf2 (2)

Mitochondrial Metabolism (2)

HBV (2)

Aurora Kinase (2)

Mitophagy (2)

Tyrosine Kinases (2)

PKC (1)

Chloride channel (1)

Serine/threonin kinase (1)

PTEN (1)

PLK (1)

HIF (1)

Progesterone Receptor (1)

Integrin (1)

Adrenergic Receptor (1)

Amylase (1)

AChR (1)

LTR (1)

Syk (1)

Dynamin (1)

c-Myc (1)

NADPH-oxidase (1)

S6 Kinase (1)

Ras (1)

Cysteine Protease (1)

DHFR (1)

PKA (1)

CFTR (1)

MLK (1)

Estrogen Receptor/ERR (1)

BCL (1)

PKM (1)

TRP/TRPV Channel (1)

ACK (1)

PAD (1)

UGT (1)

BCRP (1)

DNA/RNA Synthesis (1)

PGE Synthase (1)

MAPK (1)

JNK (1)

MNK (1)

NAMPT (1)

Tie-2 (1)

Phosphatase (1)

Prostaglandin Receptor (1)

Antifungal (1)

DNA (1)

Trk receptor (1)

MyD88 (1)

Sirtuin (1)

Histone Acetyltransferase (1)

Decarboxylase (1)

Antifection (1)

hCE (1)

IGF-1R (1)

E1/E2/E3 Enzyme (1)

VDA (1)

Beta Amyloid (1)

Reverse Transcriptase (1)

Ligands for Target Protein for PROTAC (1)

Amino Acids and Derivatives (1)

iGluR (1)

Leukotriene Receptor (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty