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Anti-CD74 Antibody (9A838)
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Catalog No. TMAH-00220
Alias II, Ia-γ, Ia-GAMMA, HLADG, DHLAG, CD74 molecule, major histocompatibility complex, class II invariant chain
Anti-CD74 Antibody (9A838) is an antibody targeting CD74. Anti-CD74 Antibody (9A838) can be used in ELISA.
Anti-CD74 Antibody (9A838)
Anti-CD74 Antibody (9A838)
😃Good
Catalog No. TMAH-00220Alias II, Ia-γ, Ia-GAMMA, HLADG, DHLAG, CD74 molecule, major histocompatibility complex, class II invariant chain
Anti-CD74 Antibody (9A838) is an antibody targeting CD74. Anti-CD74 Antibody (9A838) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA Reactivity: Human |
| Alias | II, Ia-γ, Ia-GAMMA, HLADG, DHLAG, CD74 molecule, major histocompatibility complex, class II invariant chain |
| Ig Type | Human IgG1 |
| Clone | 9A838 |
| Reactivity | Human |
| Verified Activity | The Binding Activity of Human CD74 with Anti-CD74 recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD74 at 2 μg/mL can bind Anti-CD74 recombinant antibody, the EC50 is 1.317-1.646 ng/mL. |
| Application | ELISA |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.; [Isoform p41]: Late endosome. Lysosome. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CD74 Protein |
| Antigen Species | Human |
| Gene ID | 972 |
| Uniprot ID | |
| Biology Area | Immunology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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