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Anti-CD74 Antibody (9A838) (Synonyms: II, Ia-γ, Ia-GAMMA, HLADG, DHLAG, CD74 molecule, major histocompatibi...)

Catalog No. TMAH-00220 Copy Product Info
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Anti-CD74 Antibody (9A838) is an antibody targeting CD74. Anti-CD74 Antibody (9A838) can be used in ELISA.

Anti-CD74 Antibody (9A838)

Copy Product Info
🥰Excellent
Catalog No. TMAH-00220
Synonyms II, Ia-γ, Ia-GAMMA, HLADG, DHLAG, CD74 molecule, major histocompatibility complex, class II invariant chain

Anti-CD74 Antibody (9A838) is an antibody targeting CD74. Anti-CD74 Antibody (9A838) can be used in ELISA.

Anti-CD74 Antibody
(9A838)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2097-10 days7-10 days
100 μL$3497-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-CD74 Antibody (9A838) is an antibody targeting CD74. Anti-CD74 Antibody (9A838) can be used in ELISA.
SynonymsII, Ia-γ, Ia-GAMMA, HLADG, DHLAG, CD74 molecule, major histocompatibility complex, class II invariant chain
Ig Type
Human IgG1
Clone
9A838
Reactivity
Human
Verified Activity
The Binding Activity of Human CD74 with Anti-CD74 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD74 at 2 μg/mL can bind Anti-CD74 recombinant antibody, the EC50 is 1.317-1.646 ng/mL.
Application
Antibody Type
Monoclonal
Subcellular LocalizationCell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.; [Isoform p41]: Late endosome. Lysosome.
Tissue Specificity[Isoform p41]: In B cells, represents 10% of total CD74 expression.; [Isoform p33]: In B cells, represents 70% of total CD74 expression.
ConstructionRecombinant Antibody
PurificationAffinity-chromatography
AppearanceLiquid
FormulationPreservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
Research BackgroundPlays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human CD74 Protein
Antigen Species
Human
Gene Name
CD74
Gene ID
Uniprot ID
Biology Area
Immunology
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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