Shopping Cart

Your shopping cart is currently empty

Benzydamine

Name: Benzydamine
Brand: TargetMol
SKU: T8807
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T8807Cas No. 642-72-8

Benzydamine is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. Benzydamine is used to reduce post-surgical and post-traumatic pain and edema and to promote healing.

Benzydamine

Copy Product Info

🥰Excellent

Purity: 98.34%

Catalog No. T8807Cas No. 642-72-8

Benzydamine is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. Benzydamine is used to reduce post-surgical and post-traumatic pain and edema and to promote healing.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	In Stock	In Stock
50 mg	$118	In Stock	In Stock
100 mg	$178	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.34%

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Benzydamine AI Summary

Benzydamine exhibits multifaceted bioactivity and physicochemical properties. It stimulates cyclic guanosine monophosphate (cGMP) levels with an EC50 of 1020.0 nM, notably activating bovine soluble guanylate cyclase (sGC) and inhibiting collagen-induced platelet aggregation with an IC50 of 6670.0 nM. The compound additionally acts as an inhibitor of various enzymes, including Human Jumonji Domain Containing 2E (JMJD2E) with an IC50 of 15848.9 nM, Cytochrome P450 2D6 (7943.3 nM), and 15-human lipoxygenase 2 (12589.3 nM). It also displays activity in several enzymatic and cellular assays, such as an AC50 of 5011.87 nM for p450-cyp1a2 and 7943.28 nM for p450-cyp2d6. Pharmacokinetic profiles reveal its human intestinal absorption rate, estimated by log10(%HIA +10) = 1.987, and intrinsic clearance rates in human hepatocytes (7.76 to 17.78 mL.min^-1.g^-1). Distribution potential is indicated by a LogD7.4 of 2.4 and a pKa of 9.27. Notably, Benzydamine shows no significant hepatic side effects according to the Drug Induced Liver Injury Prediction System. Despite low efficacy against human recombinant CYP2J2 (IC50 > 50000.0 nM) and moderate antiviral activity against SARS-CoV-2 in VERO-6 cells (IC50 > 20,000.0 nM), it maintains metabolic stability in human liver microsomes, with a half-life of 0.7183 hours and intrinsic clearance of 16.1 uL/min per mg protein. Additionally, the compound has shown inhibitory potential towards human HDAC6 enzyme, albeit weakly, and exhibits significant binding affinities towards various receptors, such as human SLC6A3 (AC50 112.7 nM), DRD3 (499.6 nM), and CHRM2 (3317.3 nM). It also demonstrates antagonist activity at CHRM1 (2297.3 nM) and ADRA1A (18919.1 nM), further contributing to its intricate pharmacological profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Benzydamine is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. Benzydamine is used to reduce post-surgical and post-traumatic pain and edema and to promote healing.

Chemical Properties

Molecular Weight	309.41
Formula	C₁₉H₂₃N₃O
Cas No.	642-72-8
Smiles	C(N1C=2C(C(OCCCN(C)C)=N1)=CC=CC2)C3=CC=CC=C3
Relative Density.	1.08g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (807.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2320 mL	16.1598 mL	32.3196 mL	161.5979 mL
5 mM	0.6464 mL	3.2320 mL	6.4639 mL	32.3196 mL
10 mM	0.3232 mL	1.6160 mL	3.2320 mL	16.1598 mL
20 mM	0.1616 mL	0.8080 mL	1.6160 mL	8.0799 mL
50 mM	0.0646 mL	0.3232 mL	0.6464 mL	3.2320 mL
100 mM	0.0323 mL	0.1616 mL	0.3232 mL	1.6160 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc