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α-Zearalenol

Name: α-Zearalenol
Brand: TargetMol
SKU: T13542
Price: 108 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13542Cas No. 36455-72-8

α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).

α-Zearalenol

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Purity: 99.72%

Catalog No. T13542Cas No. 36455-72-8

α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$108	-	In Stock
25 mg	$578	-	In Stock
50 mg	$825	-	In Stock
1 mL x 10 mM (in DMSO)	$253	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.72%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).

In vitro

α-Zearalenol (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 μM α-ZOL exposure in MFC-7 cells (IC50: 12.5 μM) [1].α-Zearalenol (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells. It increases the MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells. α-Zearalenol (1-10 μM; 24 hours) reduces the expression of TNF-α, α-Zearalenol combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergically for IL-8 at high toxin concentrations [2].

Chemical Properties

Molecular Weight	320.38
Formula	C₁₈H₂₄O₅
Cas No.	36455-72-8
Smiles	C[C@H]1CCC[C@H](O)CCC\C=C\c2cc(O)cc(O)c2C(=O)O1
Relative Density.	1.174g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (187.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1213 mL	15.6065 mL	31.2129 mL	156.0647 mL
5 mM	0.6243 mL	3.1213 mL	6.2426 mL	31.2129 mL
10 mM	0.3121 mL	1.5606 mL	3.1213 mL	15.6065 mL
20 mM	0.1561 mL	0.7803 mL	1.5606 mL	7.8032 mL
50 mM	0.0624 mL	0.3121 mL	0.6243 mL	3.1213 mL
100 mM	0.0312 mL	0.1561 mL	0.3121 mL	1.5606 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc