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Venlafaxine hydrochloride

Name: Venlafaxine hydrochloride
Brand: TargetMol
SKU: T0472
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0472Cas No. 99300-78-4

Alias Wy 45030 hydrochloride, Venlafaxine HCl

Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a cyclohexanol and phenylethylamine derivative functioning as a serotonin and noradrenaline reuptake inhibitor (SNRI) used as an antidepressive agent.

Venlafaxine hydrochloride

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Purity: 99.86%

Catalog No. T0472Alias Wy 45030 hydrochloride, Venlafaxine HClCas No. 99300-78-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$50	In Stock	In Stock
25 mg	$72	In Stock	In Stock
100 mg	$98	In Stock	In Stock
200 mg	$167	In Stock	In Stock
500 mg	$278	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a cyclohexanol and phenylethylamine derivative functioning as a serotonin and noradrenaline reuptake inhibitor (SNRI) used as an antidepressive agent.
In vitro	In mice, the analgesic effect induced by Venlafaxine is significantly inhibited by naloxone, nor-BNI, and naltrexone indol, indicating involvement of kappa (κ-) and delta (δ-) opioid mechanisms, but not by β-FNA or naloxazone. In fully developed neuropathic rats, Venlafaxine reverses hyperalgesia. Venlafaxine demonstrates a dose-dependent analgesic effect with an ED50 of 46.7 mg/kg in mice.
In vivo	Venlafaxine exhibits lower potential for inhibiting the metabolism of CYP2D6 substrates compared to widely used SSRIs such as desipramine and imipramine and can also inhibit the metabolism of several other major human hepatic P450 substrate enzymes. It inhibits the binding to human noradrenaline and serotonin transporters with K(i) values of 2480 nM and 82 nM, respectively. Furthermore, venlafaxine blocks p-chloroamphetamine and 6-hydroxydopamine-induced monoamine depletion with ED(50) values of 5.9 mg/kg and 94 mg/kg.
Synonyms	Wy 45030 hydrochloride, Venlafaxine HCl

Chemical Properties

Molecular Weight	313.86
Formula	C₁₇H₂₈ClNO₂
Cas No.	99300-78-4
Smiles	Cl.COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Relative Density.	1.394 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 31.4 mg/mL (100.04 mM), Sonication is recommended.

DMSO: 40 mg/mL (127.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1861 mL	15.9307 mL	31.8613 mL	159.3067 mL
5 mM	0.6372 mL	3.1861 mL	6.3723 mL	31.8613 mL
10 mM	0.3186 mL	1.5931 mL	3.1861 mL	15.9307 mL
20 mM	0.1593 mL	0.7965 mL	1.5931 mL	7.9653 mL
50 mM	0.0637 mL	0.3186 mL	0.6372 mL	3.1861 mL
100 mM	0.0319 mL	0.1593 mL	0.3186 mL	1.5931 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc