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Kurarinone
Kurarinone, a flavonoid derived from the shrub Sophora flavescens, exhibits anti-tumor, estrogenic, and anti-inflammatory activities, and shows a strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases by suppressing pathogenic CD4(+) T-cell differentiation and the overall immune response.
Catalog No. T5S0993Cas No. 34981-26-5
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Purity:99.72%
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Kurarinone
Catalog No. T5S0993Cas No. 34981-26-5
Kurarinone, a flavonoid derived from the shrub Sophora flavescens, exhibits anti-tumor, estrogenic, and anti-inflammatory activities, and shows a strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases by suppressing pathogenic CD4(+) T-cell differentiation and the overall immune response.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $39 | In Stock | |
| 5 mg | $122 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $455 | In Stock | |
| 50 mg | $657 | In Stock | |
| 100 mg | $918 | In Stock | |
| 500 mg | $1,830 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $147 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Kurarinone, a flavonoid derived from the shrub Sophora flavescens, exhibits anti-tumor, estrogenic, and anti-inflammatory activities, and shows a strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases by suppressing pathogenic CD4(+) T-cell differentiation and the overall immune response. |
| In vitro | Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. METHODS AND RESULTS:Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, Kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay. |
| Molecular Weight | 438.51 |
| Formula | C26H30O6 |
| Cas No. | 34981-26-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (125.42 mM)  | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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