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Kurarinone

Name: Kurarinone
Brand: TargetMol
SKU: T5S0993
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S0993Cas No. 34981-26-5

Kurarinone is a flavonoid extracted from the shrub Sophora flavescens, which has anti-tumor, estrogenic and anti-inflammatory activities, and also has a strong inhibitory effect on immune responses.

Kurarinone

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Purity: 99.72%

Catalog No. T5S0993Cas No. 34981-26-5

Kurarinone is a flavonoid extracted from the shrub Sophora flavescens, which has anti-tumor, estrogenic and anti-inflammatory activities, and also has a strong inhibitory effect on immune responses.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$455	In Stock	In Stock
50 mg	$657	In Stock	In Stock
100 mg	$918	-	In Stock
500 mg	$1,830	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$135	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.72%

Appearance:Solid

Color:Yellow to Orange

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Kurarinone is a flavonoid extracted from the shrub Sophora flavescens, which has anti-tumor, estrogenic and anti-inflammatory activities, and also has a strong inhibitory effect on immune responses.
In vitro	METHODS: To test the cytotoxicity of kurarinone on HMC3 cells, we treated HMC3 cells with different concentrations of kurarinone (10, 20, 40 or 80 μM) for 24 hours. RESULTS HMC3 cell viability was reduced after treatment with 80 μM Kur. METHODS: Two human small cell lung cancer (SCLC) cell lines H1688 and H146, and an immortalized bronchial epithelial cell line BEAS-2B were treated with different concentrations of kurarinone (3.125 ~ 50 μM), and the IC50 was determined. RESULTS The IC50 values of kurarinone against H1688, H146 and BEAS-2B cells were 12.5±4.7, 30.4±5.1 and 55.8±4.9 μM respectively. [3]
In vivo	METHODS: Arthritis was reproduced in DBA/1 mice by inducing bovine type II collagen (CII) as a collagen-induced arthritis (CIA) model. After establishment of CIA, kurarinone (100 mg/kg/day) was administered orally from day 21 to day 42, and severity was determined based on symptom scoring scales and histopathology. ELISA and flow cytometry were used to detect the cytokine levels, anti-cii antibody levels, and T cell proliferation and lineage in the draining lymph nodes, respectively. RESULTS kurarinone treatment reduced the severity of arthritis in CIA mice and reduced the levels of pro-inflammatory cytokines TNF-α, IL-6, IFN-γ and IL-17A in serum and foot tissue. [1]

Chemical Properties

Molecular Weight	438.51
Formula	C₂₆H₃₀O₆
Cas No.	34981-26-5
Smiles	COc1cc(O)c(C[C@@H](CC=C(C)C)C(C)=C)c2O[C@@H](CC(=O)c12)c1ccc(O)cc1O
Relative Density.	1.266g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 235 mg/mL (535.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2804 mL	11.4022 mL	22.8045 mL	114.0225 mL
5 mM	0.4561 mL	2.2804 mL	4.5609 mL	22.8045 mL
10 mM	0.2280 mL	1.1402 mL	2.2804 mL	11.4022 mL
20 mM	0.1140 mL	0.5701 mL	1.1402 mL	5.7011 mL
50 mM	0.0456 mL	0.2280 mL	0.4561 mL	2.2804 mL
100 mM	0.0228 mL	0.1140 mL	0.2280 mL	1.1402 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc