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BET bromodomain inhibitor 3

Name: BET bromodomain inhibitor 3
Brand: TargetMol
SKU: T79084
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T79084 Copy Product Info

Purity: 99.95%

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BET bromodomain inhibitor 3 is a BET inhibitor with activity against BrdT (Ki > 40 μM). It serves as a chemical probe for studying epigenetic regulation in contraception and cancer research.

BET bromodomain inhibitor 3

Copy Product Info

🥰Excellent

Catalog No. T79084

BET bromodomain inhibitor 3 is a BET inhibitor with activity against BrdT (Ki > 40 μM). It serves as a chemical probe for studying epigenetic regulation in contraception and cancer research.

Cas No. 854137-39-6

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Pack Size	Price	USA Stock	Global Stock
5 mg	$30	-	In Stock
10 mg	$40	-	In Stock
25 mg	$63	-	In Stock
50 mg	$92	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.95%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

BET bromodomain inhibitor 3 is a BET inhibitor with activity against BrdT (Ki > 40 μM). It serves as a chemical probe for studying epigenetic regulation in contraception and cancer research.

In vitro

BET bromodomain inhibitor 3 demonstrates robust anti-proliferative activity across various hematologic cancer lines. In KMS-28PE (plasmacytoma) and AMO-1 (multiple myeloma) cells, it induces significant cell cycle arrest and apoptosis at concentrations ranging from 0.001 to 10 μM. It also shows high potency against MV4-11 leukemia cells with a GI50 of 15 nM. By downregulating anti-apoptotic factors and disrupting cell cycle progression, it effectively impairs the viability of malignant cells [1][2].

Chemical Properties

Molecular Weight	339.35
Formula	C₁₈H₁₇N₃O₄
Cas No.	854137-39-6
Smiles	O=C1OCC=2NC3=C(C(=O)N(C(=O)N3C)C)C(C4=CC=C(C=C4)C)C12

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (117.87 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9468 mL	14.7341 mL	29.4681 mL	147.3405 mL
5 mM	0.5894 mL	2.9468 mL	5.8936 mL	29.4681 mL
10 mM	0.2947 mL	1.4734 mL	2.9468 mL	14.7341 mL
20 mM	0.1473 mL	0.7367 mL	1.4734 mL	7.3670 mL
50 mM	0.0589 mL	0.2947 mL	0.5894 mL	2.9468 mL
100 mM	0.0295 mL	0.1473 mL	0.2947 mL	1.4734 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc