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Neohesperidin Dihydrochalcone

Catalog No. T2767Cas No. 20702-77-6
Alias NHDC, Neohesperidin DC, NCI-c60764

Neohesperidin Dihydrochalcone (Neohesperidin DC) is an artificial sweetener derived from citrus.

Neohesperidin Dihydrochalcone

Neohesperidin Dihydrochalcone

Purity: 100%
Catalog No. T2767Alias NHDC, Neohesperidin DC, NCI-c60764Cas No. 20702-77-6
Neohesperidin Dihydrochalcone (Neohesperidin DC) is an artificial sweetener derived from citrus.
Pack SizePriceAvailabilityQuantity
1 g$29In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Neohesperidin Dihydrochalcone (Neohesperidin DC) is an artificial sweetener derived from citrus.
In vivo
Administration of neohesperidin dihydrochalcone significantly reduces the activities of AST and ALT, both key markers of liver damage. It also inhibits the expression of NF-κB, IL-6, IL-1β, and TNF-α proteins, which are elevated in the liver of PQ-treated mice, indicating its potential protective effects on liver inflammation and damage[3]. Furthermore, studies on Wistar Crl:(WI)WU BR rats to assess the embryotoxicity and teratogenicity of neohesperidin dihydrochalcone reveal no adverse effects at dietary levels up to 5%, the highest dose investigated. At this level, rats consumed approximately 3.3 g/kg body weight/day[4], demonstrating the compound's safety at significant dosage levels.
Cell Research
WST-8 dye is used in the cell viability assay. HIT-T15 and HUVEC cells are grown and maintained in Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine calf serum. 1000 cells in each well are incubated with various concentrations of neohesperidin dihydrochalcone (50, 100, 500 μM, 1 mM) and other compounds. After treating HIT-T15 and HUVEC cells with 500 μM HOCl, WST-8 dye is added to each well, and the absorbance is detected at 420 nm with microplate reader[1].
AliasNHDC, Neohesperidin DC, NCI-c60764
Chemical Properties
Molecular Weight612.58
FormulaC28H36O15
Cas No.20702-77-6
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 100 mg/mL (163.24 mM)
DMSO: 50 mg/mL (81.62 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM1.6324 mL8.1622 mL16.3244 mL81.6220 mL
5 mM0.3265 mL1.6324 mL3.2649 mL16.3244 mL
10 mM0.1632 mL0.8162 mL1.6324 mL8.1622 mL
20 mM0.0816 mL0.4081 mL0.8162 mL4.0811 mL
50 mM0.0326 mL0.1632 mL0.3265 mL1.6324 mL
Ethanol
1mg5mg10mg50mg
100 mM0.0163 mL0.0816 mL0.1632 mL0.8162 mL

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