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Fendiline hydrochloride

Name: Fendiline hydrochloride
Brand: TargetMol
SKU: T0327
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0327Cas No. 13636-18-5

Alias Fendiline HCl

Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel.

Fendiline hydrochloride

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Purity: 99.75%

Catalog No. T0327Alias Fendiline HClCas No. 13636-18-5

Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$33	In Stock	-
100 mg	$47	Inquiry	Inquiry
200 mg	$68	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Appearance:solid

Color:White

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COA LCMS HNMR

Product Introduction

Fendiline hydrochloride AI Summary

Fendiline hydrochloride is a multi-target compound exhibiting bioactivity across various assays. It demonstrates potency in inhibiting dual action probes in a Huntington cell model, inducing genomic imprint erasure, and enhancing SMN2 splice variant expression. This compound modulates miRNAs, including miR-21, enhances lipid storage, and inhibits aldehyde dehydrogenase 1. Additionally, Fendiline hydrochloride inhibits 15-human lipoxygenase enzymes, Menin-MLL binding, and HP1-beta chromodomain interactions, while antagonizing the neuropeptide S receptor and activating Cytochrome P450 3A4. It also inhibits TGF-b, AmpC Beta-Lactamase, GPR55, histone lysine methyltransferase G9a, and Vif-A3F interactions, and induces DNA re-replication in various cell lines, showing synthetic lethality in tumor cells. Furthermore, it inhibits tyrosyl-DNA phosphodiesterases 1, exhibits gametocytocidal effects, and has a noteworthy inhibitory activity on sodium fluorescein uptake in OATP1B3 (114.64% inhibition) and OATP1B1 (90.27% inhibition) transfected CHO cells at a concentration of 10 μM. However, it showed lower efficacy in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2, with an inhibition index of -0.1844 after 72 hours, compared to the arbidol control. These diverse activities indicate its potential across multiple biological pathways and disease targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel.
Synonyms	Fendiline HCl

Chemical Properties

Molecular Weight	351.91
Formula	C₂₃H₂₆ClN
Cas No.	13636-18-5
Smiles	Cl.CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1
Relative Density.	1.031g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 35.2 mg/mL (100.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8416 mL	14.2082 mL	28.4164 mL	142.0818 mL
5 mM	0.5683 mL	2.8416 mL	5.6833 mL	28.4164 mL
10 mM	0.2842 mL	1.4208 mL	2.8416 mL	14.2082 mL
20 mM	0.1421 mL	0.7104 mL	1.4208 mL	7.1041 mL
50 mM	0.0568 mL	0.2842 mL	0.5683 mL	2.8416 mL
100 mM	0.0284 mL	0.1421 mL	0.2842 mL	1.4208 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc