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Actoxumab (Synonyms: Anti-C. difficile Toxin A Recombinant Antibody)
Catalog No. T77473 Copy Product Info
Purity: 95%
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Actoxumab is a humanized monoclonal antibody targeting Clostridium difficile toxin A (TcdA), preventing the binding of TcdA to target cells and neutralizing toxin activity by inhibiting the first step of TcdA.
Actoxumab
Copy Product Info🥰Excellent
Catalog No. T77473
Synonyms Anti-C. difficile Toxin A Recombinant Antibody
Actoxumab is a humanized monoclonal antibody targeting Clostridium difficile toxin A (TcdA), preventing the binding of TcdA to target cells and neutralizing toxin activity by inhibiting the first step of TcdA.
Actoxumab
Cas No. 1245634-25-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $332 | In Stock | In Stock | |
| 5 mg | $996 | In Stock | In Stock | |
| 10 mg | $1,577 | - | In Stock | |
| 25 mg | $2,680 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.52% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Actoxumab is a humanized monoclonal antibody targeting Clostridium difficile toxin A (TcdA), preventing the binding of TcdA to target cells and neutralizing toxin activity by inhibiting the first step of TcdA. |
| In vitro | Actoxumab (10 mg/kg) significantly inhibited cell rounding activity in Vero cells when treated with 2 ng/mL TcdA. [1] |
| In vivo | Actoxumab-bezlotoxumab (0.1, 1 or 10 mg/kg) significantly protected mice in a dose-dependent manner from Clostridium difficile toxin attack models. In acute and severe CDI models, Actoxumab-bezlotoxumab prevents inflammation and damage associated with TcdA and TcdB. [1] |
| Synonyms | Anti-C. difficile Toxin A Recombinant Antibody |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | Cdiff Toxin A |
| Molecular Weight | 145 kDa |
| Cas No. | 1245634-25-6 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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