Integrin alpha V beta 6 Protein, Human, Recombinant (Avi & His)

Catalog No. TMPY-03878U

Integrin alpha V beta 6 Protein, Human, Recombinant (Avi & His) is expressed in HEK293 Cells. The accession number is P06756-1(ITGAV)&P18564-1(ITGB6).

Integrin alpha V beta 6 Protein, Human, Recombinant (Avi & His)

Catalog No. TMPY-03878U

Integrin alpha V beta 6 Protein, Human, Recombinant (Avi & His) is expressed in HEK293 Cells. The accession number is P06756-1(ITGAV)&P18564-1(ITGB6).

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Product Information

Biological Activity	Immobilized Human ITGAV&ITGB6, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.49 μg/ml determined by ELISA.
Description	Integrin alpha V beta 6 Protein, Human, Recombinant (Avi & His) is expressed in HEK293 Cells. The accession number is P06756-1(ITGAV)&P18564-1(ITGB6).
Species	Human
Expression System	HEK293 Cells
Accession Number	P06756-1(ITGAV)&P18564-1(ITGB6)
Synonyms	ITGAV & ITGB6,integrin, α5 (fibronectin receptor, α polypeptide),integrin, alpha 5 (fibronectin receptor, alpha polypeptide),Integrin α V β 6,Integrin alpha V β6
Construction	Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	114 kDa (ITGAV) & 79.1 kDa (ITGB6) (Predicted); 90-150 kDa (Due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.