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mTOR inhibitor WYE-28

Name: mTOR inhibitor WYE-28
Brand: TargetMol
SKU: T36307
Price: 85 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36307Cas No. 1062172-60-4

Alias mTOR inhibitor WYE28, mTOR inhibitor WYE 28

mTOR inhibitor WYE-28 (compound 28) is an mTOR inhibitor (IC50 = 0.08 nM) and PI3Kα inhibitor (IC50 = 6 nM) with a half-life of 13 minutes in nude mouse microsomes.

mTOR inhibitor WYE-28

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Purity: 98.13%

Catalog No. T36307Alias mTOR inhibitor WYE28, mTOR inhibitor WYE 28Cas No. 1062172-60-4

mTOR inhibitor WYE-28 (compound 28) is an mTOR inhibitor (IC50 = 0.08 nM) and PI3Kα inhibitor (IC50 = 6 nM) with a half-life of 13 minutes in nude mouse microsomes.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$85	-	In Stock
5 mg	$297	-	In Stock
10 mg	$496	-	In Stock
25 mg	$993	-	In Stock
50 mg	$1,330	-	In Stock
100 mg	$1,780	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.13%

Appearance:Solid

Color:Orange

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	mTOR inhibitor WYE-28 (compound 28) is an mTOR inhibitor (IC50 = 0.08 nM) and PI3Kα inhibitor (IC50 = 6 nM) with a half-life of 13 minutes in nude mouse microsomes.
Targets&IC50	PI3Kα:6 nM, mTOR:0.08 nM
Synonyms	mTOR inhibitor WYE28, mTOR inhibitor WYE 28

Chemical Properties

Molecular Weight	586.65
Formula	C₃₀H₃₄N₈O₅
Cas No.	1062172-60-4
Smiles	O=C(OC)N1CCC(N2N=CC=3C2=NC(=NC3N4CCOCC4)C=5C=CC(=CC5)NC(=O)NC6=CC=C(C=C6)CO)CC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45.00 mg/mL (76.71 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7046 mL	8.5230 mL	17.0459 mL	85.2297 mL
5 mM	0.3409 mL	1.7046 mL	3.4092 mL	17.0459 mL
10 mM	0.1705 mL	0.8523 mL	1.7046 mL	8.5230 mL
20 mM	0.0852 mL	0.4261 mL	0.8523 mL	4.2615 mL
50 mM	0.0341 mL	0.1705 mL	0.3409 mL	1.7046 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc