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mTOR inhibitor WYE-28

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Catalog No. T36307Cas No. 1062172-60-4
Alias mTOR inhibitor WYE28, mTOR inhibitor WYE 28

mTOR inhibitor WYE-28 (compound 28) is an mTOR inhibitor (IC50 = 0.08 nM) and PI3Kα inhibitor (IC50 = 6 nM) with a half-life of 13 minutes in nude mouse microsomes.

mTOR inhibitor WYE-28

mTOR inhibitor WYE-28

😃Good
Catalog No. T36307Alias mTOR inhibitor WYE28, mTOR inhibitor WYE 28Cas No. 1062172-60-4
mTOR inhibitor WYE-28 (compound 28) is an mTOR inhibitor (IC50 = 0.08 nM) and PI3Kα inhibitor (IC50 = 6 nM) with a half-life of 13 minutes in nude mouse microsomes.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 μg$159-In Stock
1 mg$297-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
mTOR inhibitor WYE-28 (compound 28) is an mTOR inhibitor (IC50 = 0.08 nM) and PI3Kα inhibitor (IC50 = 6 nM) with a half-life of 13 minutes in nude mouse microsomes.
Targets&IC50
PI3Kα:6 nM, mTOR:0.08 nM
SynonymsmTOR inhibitor WYE28, mTOR inhibitor WYE 28
Chemical Properties
Molecular Weight586.65
FormulaC30H34N8O5
Cas No.1062172-60-4
SmilesO=C(OC)N1CCC(N2N=CC=3C2=NC(=NC3N4CCOCC4)C=5C=CC(=CC5)NC(=O)NC6=CC=C(C=C6)CO)CC1
ColorOrange
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45.00 mg/mL (76.71 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7046 mL8.5230 mL17.0459 mL85.2297 mL
5 mM0.3409 mL1.7046 mL3.4092 mL17.0459 mL
10 mM0.1705 mL0.8523 mL1.7046 mL8.5230 mL
20 mM0.0852 mL0.4261 mL0.8523 mL4.2615 mL
50 mM0.0341 mL0.1705 mL0.3409 mL1.7046 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Compound 28
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