Anti-GRIA2 Polyclonal Antibody

Name: Anti-GRIA2 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00811
Rating: 4.5 (1 reviews)

(Synonyms: GRIA2, Glutamate receptor ionotropic, AMPA 2, Glutamate receptor 2, GluR-K2, GluR-B, GluR-2, GLUR2, GluA2, AMPA-selective glutamate receptor 2) Copy Product Info

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Synonyms: GRIA2, Glutamate receptor ionotropic, AMPA 2, Glutamate receptor 2, GluR-K2, GluR-B, GluR-2, GLUR2, GluA2, AMPA-selective glutamate receptor 2

Catalog No. TMAB-00811 Copy Product Info

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Anti-GRIA2 Polyclonal Antibody is a Rabbit antibody targeting GRIA2. Anti-GRIA2 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.

Anti-GRIA2 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$221	7-10 days	7-10 days
100 μL	$372	7-10 days	7-10 days
200 μL	$527	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-GRIA2 Polyclonal Antibody is a Rabbit antibody targeting GRIA2. Anti-GRIA2 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.
Synonyms	GRIA2, Glutamate receptor ionotropic, AMPA 2, Glutamate receptor 2, GluR-K2, GluR-B, GluR-2, GLUR2, GluA2, AMPA-selective glutamate receptor 2
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Dog,Pig)

Application	FCM IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg /test
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing(CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human GluR2
Antigen Species	Human
Gene Name	GRIA2
Gene ID	2891
Protein Name	Glutamate receptor 2
Uniprot ID	P42262
Biology Area	Glutamate Receptors,Glutamate
Function	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.