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Palbociclib-d8

Name: Palbociclib-d8
Brand: TargetMol
SKU: T12355
Rating: 4.5 (1 reviews)

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Catalog No. T12355Cas No. 1628752-83-9

Alias PD0332991 D8, PD 0332991 D8, Palbociclib D8

Palbociclib-d8 (PD 0332991 D8) is the 2H-labeled form of Palbociclib. Palbociclib is an orally active CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM). Palbociclib has anti-tumor activity and is used in research for estrogen receptor-positive and HER2-negative breast cancer.

Palbociclib-d8

😃Good

Catalog No. T12355Alias PD0332991 D8, PD 0332991 D8, Palbociclib D8Cas No. 1628752-83-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$489	35 days	35 days
5 mg	$1,080	7-10 days	7-10 days
10 mg	$1,620	7-10 days	7-10 days
25 mg	$2,750	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White to Yellow

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COA

Product Introduction

Bioactivity

Description	Palbociclib-d8 (PD 0332991 D8) is the 2H-labeled form of Palbociclib. Palbociclib is an orally active CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM). Palbociclib has anti-tumor activity and is used in research for estrogen receptor-positive and HER2-negative breast cancer.
Targets&IC50	CDK4-CyclinD3:9 nM, CDK6-CyclinD2:16 nM, CDK4-CyclinD1:11 nM, DYRK1A:2000 nM, MAPK:8000 nM
Synonyms	PD0332991 D8, PD 0332991 D8, Palbociclib D8

Chemical Properties

Molecular Weight	455.58
Formula	C₂₄H₂₁D₈N₇O₂
Cas No.	1628752-83-9
Smiles	O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4C(C(NC(C4([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])N2)C5CCCC5
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 5 mg/mL (10.98 mM), when pH is adjusted to 3 with 1M HCl, sonication and heating are recommended.

DMSO: 1 mg/mL (2.2 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.1950 mL	10.9750 mL	21.9500 mL	109.7502 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.4390 mL	2.1950 mL	4.3900 mL	21.9500 mL
10 mM	0.2195 mL	1.0975 mL	2.1950 mL	10.9750 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc