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KGP94

Name: KGP94
Brand: TargetMol
SKU: T27730
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27730Cas No. 1131456-28-4

Alias KGP-94, KGP 94

KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.

KGP94

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Purity: 99.6%

Catalog No. T27730Alias KGP-94, KGP 94Cas No. 1131456-28-4

KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.

Pack Size	Price	Availability
1 mg	$63	In Stock
5 mg	$148	In Stock
10 mg	$238	In Stock
25 mg	$398	In Stock
50 mg	$567	In Stock
100 mg	$768	In Stock
200 mg	$1,030	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.6%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.
In vitro	The novel cathepsin L/K inhibitors KGP94 could inhibit in vitro M2 macrophage invasion and reduce the macrophage-stimulated invasion of 4T1 murine breast cancer cells. KGP94 treatment also reduced the expression of several M2-associated markers, suggesting that cathepsin L activity may be important for IL-4-driven M0 to M2 differentiation[1].
Synonyms	KGP-94, KGP 94

Chemical Properties

Molecular Weight	350.23
Formula	C₁₄H₁₂BrN₃OS
Cas No.	1131456-28-4
Smiles	NC(=S)N\N=C(\c1cccc(O)c1)c1cccc(Br)c1
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (171.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8553 mL	14.2763 mL	28.5527 mL	142.7633 mL
5 mM	0.5711 mL	2.8553 mL	5.7105 mL	28.5527 mL
10 mM	0.2855 mL	1.4276 mL	2.8553 mL	14.2763 mL
20 mM	0.1428 mL	0.7138 mL	1.4276 mL	7.1382 mL
50 mM	0.0571 mL	0.2855 mL	0.5711 mL	2.8553 mL
100 mM	0.0286 mL	0.1428 mL	0.2855 mL	1.4276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc