Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 629.00 | |
50 mg | In stock | $ 896.00 | |
100 mg | In stock | $ 1,220.00 | |
500 mg | In stock | $ 2,450.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 272.00 |
Description | CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production. |
In vitro | CL097 (0, 0.5, 2.5, 5, and 10 μg/mL) induces hyperactivation of the NADPH oxidase by stimulating the phosphorylation of p47phox on selective sites in human neutrophils[1]. CL097 (0.1 μM) induces activation of NF-κB in TLR7-transfected HEK293 cells and at 4 μM in TLR8-transfected HEK293 cells[3]. |
In vivo | in NOD mice, CL097 (5 mg/kg, s.c.) causes a modest specific lysis of the target peptide (∼25%). However, treatment with a combination of CL097 and CD40 agonist (10 mg/kg, i.p.) results in an increase of approximately twofold in the specific lysis of the IGRP-peptide-coated targets compared with CL097 treatment alone[2]. |
Synonyms | CL097 |
Molecular Weight | 242.28 |
Formula | C13H14N4O |
CAS No. | 1026249-18-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (392.11 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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CL097 1026249-18-2 Immunology/Inflammation Metabolism NF-Κb TLR Reactive Oxygen Species Immunological CL-097 inhibit Oligonucleotide Toll-like Receptor (TLR) Peptide TLR7 Heterocycle modulators Inhibitor CL 097 TLR8 inhibitor