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Anti-PDGFRA Antibody (5I344)
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Catalog No. TMAY-00968
Alias platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide
Anti-PDGFRA Antibody (5I344) is a Mouse antibody targeting PDGFRA. Anti-PDGFRA Antibody (5I344) can be used in ELISA.
Anti-PDGFRA Antibody (5I344)
Anti-PDGFRA Antibody (5I344)
😃Good
Catalog No. TMAY-00968Alias platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide
Anti-PDGFRA Antibody (5I344) is a Mouse antibody targeting PDGFRA. Anti-PDGFRA Antibody (5I344) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $293 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PDGFRA Antibody (5I344) is a Mouse antibody targeting PDGFRA. Anti-PDGFRA Antibody (5I344) can be used in ELISA. |
| Alias | platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 5I344 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human extracellular domain PDGFRa / CD140a (rh PDGFRa; TMPY-01139; NP_006197.1; Met 1-Glu 524). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CD140a protein (TMPY-01139) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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