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Mesoridazine Besylate

Name: Mesoridazine Besylate
Brand: TargetMol
SKU: T3086
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3086Cas No. 32672-69-8

Alias Serentil, Mesoridazine benzenesulfonate

Mesoridazine Besylate (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine.

Mesoridazine Besylate

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Purity: 98.87%

Catalog No. T3086Alias Serentil, Mesoridazine benzenesulfonateCas No. 32672-69-8

Mesoridazine Besylate (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$70	In Stock	In Stock
10 mg	$132	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.87%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Mesoridazine Besylate AI Summary

Mesoridazine Besylate exhibits potential bioactivity across a range of biological pathways and targets. It inhibits histone lysine methyltransferase G9a, Chronic Active B-Cell Receptor Signaling, and human tyrosyl-DNA phosphodiesterase 1, while also inducing synthetic lethality in tumor cells producing 2HG. In antiviral assays, it demonstrates inhibitory effects against SARS-CoV-2, reducing cytotoxicity in both Vero E6 and Caco-2 cells and shows activity against the SARS-CoV-2 3CL-Pro enzyme. Specifically, it exhibits an inhibition index of 0.3037 in cell viability assays and variable inhibition percentages in different experimental setups. In addition, Mesoridazine Besylate shows moderate antifungal and antibacterial activity against several pathogens, including Candida albicans, Cryptococcus neoformans, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, with varying inhibition rates. However, its efficacy is lower against Klebsiella pneumoniae and significantly reduced against Staphylococcus aureus MRSA..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Mesoridazine Besylate (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine.
Synonyms	Serentil, Mesoridazine benzenesulfonate

Chemical Properties

Molecular Weight	544.75
Formula	C₂₇H₃₂N₂O₄S₃
Cas No.	32672-69-8
Smiles	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C.c1ccc(cc1)S(=O)(=O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (100.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8357 mL	9.1785 mL	18.3570 mL	91.7852 mL
5 mM	0.3671 mL	1.8357 mL	3.6714 mL	18.3570 mL
10 mM	0.1836 mL	0.9179 mL	1.8357 mL	9.1785 mL
20 mM	0.0918 mL	0.4589 mL	0.9179 mL	4.5893 mL
50 mM	0.0367 mL	0.1836 mL	0.3671 mL	1.8357 mL
100 mM	0.0184 mL	0.0918 mL	0.1836 mL	0.9179 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc