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TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

Fedratinib hydrochloride hydrate

🥰Excellent
Catalog No. T9251Cas No. 1374744-69-0
Alias TG-101348 hydrochloride hydrate, SAR 302503 hydrochloride hydrate

Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.

Fedratinib hydrochloride hydrate
Other Forms of Fedratinib hydrochloride hydrate:
FedratinibT1995936091-26-8
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Fedratinib hydrochloride hydrate

🥰Excellent
Purity: 99.87%
Catalog No. T9251Alias TG-101348 hydrochloride hydrate, SAR 302503 hydrochloride hydrateCas No. 1374744-69-0
Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.
Pack SizePriceAvailabilityQuantity
5 mg$39In Stock
10 mg$55In Stock
25 mg$78In Stock
50 mg$102In Stock
100 mg$122In Stock
200 mg$197In Stock
1 mL x 10 mM (in DMSO)$61In Stock
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.87%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.
Targets&IC50
JAK2 (V617F):3 nM, JAK2:3 nM, FLT3:15 nM, RET:48 nM
SynonymsTG-101348 hydrochloride hydrate, SAR 302503 hydrochloride hydrate
Chemical Properties
Molecular Weight615.61
FormulaC27H40Cl2N6O4S
Cas No.1374744-69-0
SmilesO.Cl.Cl.Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 120 mg/mL (194.92 mM), Sonication is recommended.
H2O: 97 mg/mL (157.56 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.6244 mL8.1220 mL16.2441 mL81.2203 mL
5 mM0.3249 mL1.6244 mL3.2488 mL16.2441 mL
10 mM0.1624 mL0.8122 mL1.6244 mL8.1220 mL
20 mM0.0812 mL0.4061 mL0.8122 mL4.0610 mL
50 mM0.0325 mL0.1624 mL0.3249 mL1.6244 mL
100 mM0.0162 mL0.0812 mL0.1624 mL0.8122 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TG-101348 hydrochloride HydrateTG-101348 hydrochlorideSTAT5SAR 302503 hydrochloride HydrateSAR 302503 hydrochlorideRETphosphorylationorallymyeloproliferativeJanus kinaseJAK2V617FJAK2 (V617F)JAK2JAKInhibitorinhibitFLT3Fedratinib hydrochloride HydrateFedratinib hydrochloride hydrateFedratinib hydrochlorideApoptosisanti-proliferationanti-cancer
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