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N-Nitrosodiethylamine

Name: N-Nitrosodiethylamine
Brand: TargetMol
SKU: T35455
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35455Cas No. 55-18-5

Alias NDEA, Diethylnitrosamine

N-Nitrosodiethylamine (NDEA) is a carcinogenic dialkylnitrosamine commonly found in water, tobacco smoke, cheddar cheese, pickled foods, fried foods, and various alcoholic beverages; it is associated with alterations in nucleases involved in DNA repair and replication, targets organs such as the nasal cavity, trachea, lungs, esophagus, and liver to induce tumors in animals, and is most commonly used to induce liver cancer models.

N-Nitrosodiethylamine

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Purity: 99.99%

Catalog No. T35455Alias NDEA, DiethylnitrosamineCas No. 55-18-5

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$41	In Stock	In Stock
1 g	$56	In Stock	In Stock
5 g	$129	-	In Stock
1 mL x 10 mM (in DMSO)	$44	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Appearance:Liquid

Color:Transparent to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	N-Nitrosodiethylamine (NDEA) is a carcinogenic dialkylnitrosamine commonly found in water, tobacco smoke, cheddar cheese, pickled foods, fried foods, and various alcoholic beverages; it is associated with alterations in nucleases involved in DNA repair and replication, targets organs such as the nasal cavity, trachea, lungs, esophagus, and liver to induce tumors in animals, and is most commonly used to induce liver cancer models.
In vivo	Mice with N-Nitrosodiethylamine (25mg/kg) intraperitonially resulted in fatty liver disease leading to progress of cancer disease.
Synonyms	NDEA, Diethylnitrosamine

Chemical Properties

Molecular Weight	102.14
Formula	C₄H₁₀N₂O
Cas No.	55-18-5
Smiles	CCN(CC)N=O

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 98 mg/mL (959.47 mM), Sonication is recommended.

DMSO: 50 mg/mL (489.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (19.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	9.7905 mL	48.9524 mL	97.9048 mL	489.5242 mL
5 mM	1.9581 mL	9.7905 mL	19.5810 mL	97.9048 mL
10 mM	0.9790 mL	4.8952 mL	9.7905 mL	48.9524 mL
20 mM	0.4895 mL	2.4476 mL	4.8952 mL	24.4762 mL
50 mM	0.1958 mL	0.9790 mL	1.9581 mL	9.7905 mL
100 mM	0.0979 mL	0.4895 mL	0.9790 mL	4.8952 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc