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Cannabigerol
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Catalog No. TN1465Cas No. 25654-31-3
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressure, which may be of benefit in the treatment of glaucoma.
Cannabigerol
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Purity: 99.92%
Catalog No. TN1465Cas No. 25654-31-3
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressure, which may be of benefit in the treatment of glaucoma.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $148 | In Stock | In Stock | |
| 2 mg | $226 | In Stock | In Stock | |
| 5 mg | $331 | In Stock | In Stock | |
| 10 mg | $498 | In Stock | In Stock | |
| 25 mg | $851 | In Stock | In Stock | |
| 50 mg | $1,170 | - | In Stock | |
| 100 mg | $1,580 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $341 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.92%
Appearance:Solid
Color:White
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Product Introduction
Cannabigerol AI Summary
Cannabigerol exhibits a diverse range of bioactivities. It shows antibacterial activity against various methicillin-resistant and macrolide-resistant strains of Staphylococcus aureus, including specific strains like SA1199B and RN4220, with a minimum inhibitory concentration (MIC) of 1.0 ug/mL after 18 hours of exposure. This compound also targets tetracycline-resistant strains such as XU212. For epidemic strains 15 and 16 of methicillin-resistant Staphylococcus aureus, the MIC values are 2.0 ug/mL and 1.0 ug/mL, respectively.
In addition to its antibacterial properties, Cannabigerol exhibits agonist activity at the rat TRPA1 channel, increasing intracellular calcium influx with an EC50 of 3400.0 nM. It interacts with cannabinoid receptors CB1 and CB2, where it displaces [3H]-CP55940 with Ki values of 153.0 nM (CB2) and 897.0 nM (CB1). The compound also affects various TRP receptors such as TRPV1, TRPV2, TRPA1, and TRPM8, exhibiting both agonist and antagonist activities, with a notable IC50 value of 160.0 nM for TRPM8 antagonism.
Moreover, Cannabigerol demonstrates multiple other bioactivities: it inhibits FAAH in rat brain membranes (IC50 > 100,000 nM) and MAGL in African green monkey COS cell homogenates (IC50 95,700.0 nM). It also inhibits recombinant human DAGLalpha (IC50 > 100,000 nM) and shows an IC50 of 11,300.0 nM for the uptake of [14C]-AEA in rat RBL2H3 cells. It has agonist activity at GAL4-tagged PPARgamma with an EC50 value of 15700.0 nM and shows inhibition of human LDHB reducing lactate production by less than 50% at 10 uM.
Cannabigerol also demonstrates antihemolytic potency against erythrocytes subjected to hypotonic lysis and substantial inhibition of lysophosphatidylcholine acyltransferase in mouse brains. It exhibits antibiofilm and antimicrobial activities against methicillin-resistant Staphylococcus aureus USA300 and displays antimycobacterial activity against Escherichia coli in conjunction with polymyxin..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressure, which may be of benefit in the treatment of glaucoma. |
| Molecular Weight | 316.48 |
| Formula | C21H32O2 |
| Cas No. | 25654-31-3 |
| Smiles | C(CCCC)C1=CC(O)=C(C/C=C(/CCC=C(C)C)\C)C(O)=C1 |
| Relative Density. | 0.987g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 65 mg/mL (205.38 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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