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SIS17

Name: SIS17
Brand: TargetMol
SKU: T5631
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5631Cas No. 2374313-54-7

SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

SIS17

🥰Excellent

Purity: 98.22%

Catalog No. T5631Cas No. 2374313-54-7

Pack Size	Price	Availability
5 mg	$59	In Stock
10 mg	$98	In Stock
25 mg	$189	In Stock
50 mg	$322	In Stock
100 mg	$513	In Stock

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Batch Information

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Purity:98.22%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
Targets&IC50	HDAC11:0.83 μM (IC50)
In vitro	SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

Chemical Properties

Molecular Weight	366.6
Formula	C₂₁H₃₈N₂OS
Cas No.	2374313-54-7
Smiles	CCCCCCCCCCCCCCCCNNC(=O)c1cccs1
Relative Density.	0.975 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (340.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7278 mL	13.6388 mL	27.2777 mL	136.3884 mL
5 mM	0.5456 mL	2.7278 mL	5.4555 mL	27.2777 mL
10 mM	0.2728 mL	1.3639 mL	2.7278 mL	13.6388 mL
20 mM	0.1364 mL	0.6819 mL	1.3639 mL	6.8194 mL
50 mM	0.0546 mL	0.2728 mL	0.5456 mL	2.7278 mL
100 mM	0.0273 mL	0.1364 mL	0.2728 mL	1.3639 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc