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MMPIP hydrochloride
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Catalog No. T23008LCas No. 1215566-78-1
Alias MMPIP hydrochloride (479077-02-6 Free base)
MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions.
MMPIP hydrochloride
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Purity: 99.88%
Catalog No. T23008LAlias MMPIP hydrochloride (479077-02-6 Free base)Cas No. 1215566-78-1
MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $54 | In Stock | In Stock | |
| 5 mg | $128 | In Stock | In Stock | |
| 10 mg | $213 | In Stock | In Stock | |
| 25 mg | $438 | In Stock | In Stock | |
| 50 mg | $649 | In Stock | In Stock | |
| 100 mg | $926 | In Stock | In Stock | |
| 200 mg | $1,260 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $143 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.88%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions. |
| In vitro | In CHO cells coexpressing rat mGluR7 with Gα15, MMPIP hydrochloride inhibits L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; 0.5 mM)-induced intracellular Ca2+ mobilization with an IC50 of 26 nM. MMPIP hydrochloride also antagonizes L-AP4-induced inhibition of cAMP accumulation with an IC50 of 610 nM. MMPIP hydrochloride inhibits L-AP4-induced inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing rat mGluR7[1]. |
| In vivo | MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. MMPIP hydrochloride (10 mg/kg; i.p.) rescues the MK-801 (0.1 mg/kg)-induced cognitive impairments, by improving the choice accuracy. MMPIP hydrochloride (10 mg/kg) attenuates the amplitude of the acoustic startle response and markedly enhances the prepulse-induced inhibition of the acoustic startle response (up to 137% of control)[2]. |
| Synonyms | MMPIP hydrochloride (479077-02-6 Free base) |
| Molecular Weight | 369.8 |
| Formula | C19H16ClN3O3 |
| Cas No. | 1215566-78-1 |
| Smiles | Cl.COc1ccc(cc1)-c1cc2onc(-c3ccncc3)c2c(=O)n1C |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.7 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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