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Anti-DKK2 Polyclonal Antibody
😃Good
Catalog No. TMAB-00549
Alias hDkk-2, Dkk-2, DKK2, Dickkopf-related protein 2, Dickkopf-2
Anti-DKK2 Polyclonal Antibody is a Rabbit antibody targeting DKK2. Anti-DKK2 Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
Anti-DKK2 Polyclonal Antibody
Anti-DKK2 Polyclonal Antibody
😃Good
Catalog No. TMAB-00549Alias hDkk-2, Dkk-2, DKK2, Dickkopf-related protein 2, Dickkopf-2
Anti-DKK2 Polyclonal Antibody is a Rabbit antibody targeting DKK2. Anti-DKK2 Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-DKK2 Polyclonal Antibody is a Rabbit antibody targeting DKK2. Anti-DKK2 Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB. |
| Synonyms | hDkk-2, Dkk-2, DKK2, Dickkopf-related protein 2, Dickkopf-2 |
| Ig Type | IgG |
| Reactivity | (predicted:Human,Mouse,Rat,Chicken,Dog,Pig,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted. |
| Tissue Specificity | Expressed in heart, brain, skeletal muscle and lung. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human DKK2 |
| Antigen Species | Human |
| Gene Name | DKK2 |
| Gene ID | |
| Protein Name | Dickkopf-related protein 2 |
| Uniprot ID | |
| Biology Area | Secreted |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Molecular Weight | Theoretical: 25 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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