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NSC23005 Sodium

Name: NSC23005 Sodium
Brand: TargetMol
SKU: T3589
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3589Cas No. 1796596-46-7

NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) that promotes Hematopoietic stem cells (HSCs) expansion in both murine and human models.

NSC23005 Sodium

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Purity: 99.64%

Catalog No. T3589Cas No. 1796596-46-7

NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) that promotes Hematopoietic stem cells (HSCs) expansion in both murine and human models.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$112	In Stock	In Stock
25 mg	$225	In Stock	In Stock
50 mg	$349	In Stock	In Stock
100 mg	$546	-	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.64%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) that promotes Hematopoietic stem cells (HSCs) expansion in both murine and human models.
Targets&IC50	p18INK4C:5.21 nM (ED50)
In vitro	NSC23005 sodium is a novel class of INK4C (p18INK4C or p18) small molecule inhibitor (p18SMIs), which is initially found by in silico 3D screening. NSC23005 sodium shows the most potent bioactivity in hematopoietic stem cells (HSCs) expansion (ED50=5.21 nM). Notably, NSC23005 sodium does not show significant cytotoxicity toward 32D cells or HSCs, nor does it augment leukemia cell proliferation. NSC23005 sodium (ED50=5.21 nM), shows no activity in promoting the proliferation of leukemia cells.
In vivo	NSC23005 sodium selectively promotes HSC division by inhibiting p18, thereby activating CDK4/6. This novel and effective p18 inhibitor enhances HSC expansion in both murine and human models without significant cytotoxicity toward HSCs, and it does not augment leukemia cell proliferation.
Cell Research	NSC23005 sodium is dissolved in DMSO and stored, and then diluted with appropriate medium before use[1]. c-Kit enriched bone marrow (BM) cells are cultured for 5 days with cytokine combination plus NSC23005 sodium or DMSO. As positive controls, primary uncultured bone marrow cells are treated by ultraviolet radiation (UV) for 10 minutes prior to the staining process for apoptosis analysis. Apoptosis and cell death are measured by AnnexinV and DAPI staining in the Annexin V-FITC Apoptosis Detection Kit. Apoptosis is measured on an FACS analyzer. The data is analyzed using FlowJo software[1].

Chemical Properties

Molecular Weight	305.32
Formula	C₁₃H₁₆NNaO₄S
Cas No.	1796596-46-7
Smiles	C1CCC(CC1)NS(=O)(=O)c1ccc(cc1)C(=O)[O-].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (196.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2753 mL	16.3763 mL	32.7525 mL	163.7626 mL
5 mM	0.6551 mL	3.2753 mL	6.5505 mL	32.7525 mL
10 mM	0.3275 mL	1.6376 mL	3.2753 mL	16.3763 mL
20 mM	0.1638 mL	0.8188 mL	1.6376 mL	8.1881 mL
50 mM	0.0655 mL	0.3275 mL	0.6551 mL	3.2753 mL
100 mM	0.0328 mL	0.1638 mL	0.3275 mL	1.6376 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc