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Anti-HDPTP Polyclonal Antibody

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Catalog No. TMAB-06954

Anti-HDPTP Polyclonal Antibody is a Rabbit antibody targeting HDPTP. Anti-HDPTP Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.

Anti-HDPTP Polyclonal Antibody

Anti-HDPTP Polyclonal Antibody

😃Good
Catalog No. TMAB-06954
Anti-HDPTP Polyclonal Antibody is a Rabbit antibody targeting HDPTP. Anti-HDPTP Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2217-10 days7-10 days
100 μL$3717-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-HDPTP Polyclonal Antibody is a Rabbit antibody targeting HDPTP. Anti-HDPTP Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
Reactivity
Human,Rat (predicted:Mouse,Chicken,Pig)
Application
IHC-P
IHC-Fr
IF
FCM
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundHD-PTP is a 1,636 amino acid protein encoded by the human gene PTPN23. HD-PTP belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily. It contains one BRO1 domain, two TPR repeats and one tyrosine-protein phosphatase domain. The C-terminal region contains the PTP-like domain, whereas the N-terminal region contains the two TPR regions. These regions are homologous to the yeast protein, BRO1, which is involved in the mitogen-activated protein kinase signaling pathway. Similarly, HD-PTP is believed to act as a negative regulator of Ras-mediated mitogenic activity and is phosphorylated upon DNA damage, probably by ATM or ATR. HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor (VEGF) has no affect on protein levels, Fibroblast Growth Factor-2 (FGF-2) induces HD-PTP degradation via the proteasome system.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human HDPTP
Antigen Species
Human
Gene Name
PTPN23
Gene ID
25930
Protein Name
Tyrosine-protein phosphatase non-receptor type 23
Uniprot ID
Q8N6Z5
Function
May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
Chemical Properties
Molecular WeightTheoretical: 179 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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