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7BIO

🥰Excellent
Catalog No. T22012Cas No. 916440-85-2

7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.

7BIO

7BIO

🥰Excellent
Purity: 99.67%
Catalog No. T22012Cas No. 916440-85-2
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$38In StockIn Stock
10 mg$58In StockIn Stock
25 mg$118In StockIn Stock
50 mg$188In StockIn Stock
100 mg$298-In Stock
200 mg$423-In Stock
1 mL x 10 mM (in DMSO)$44In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.67%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.
Chemical Properties
Molecular Weight356.17
FormulaC16H10BrN3O2
Cas No.916440-85-2
SmilesO\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2c1cccc2Br
Relative Density.1.80±0.1 g/cm3 (20 °C, 760 mmHg)
ColorRed
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: Soluble
DMSO: 36.67 mg/mL (102.96 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.62 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8076 mL14.0382 mL28.0765 mL140.3824 mL
5 mM0.5615 mL2.8076 mL5.6153 mL28.0765 mL
10 mM0.2808 mL1.4038 mL2.8076 mL14.0382 mL
20 mM0.1404 mL0.7019 mL1.4038 mL7.0191 mL
50 mM0.0562 mL0.2808 mL0.5615 mL2.8076 mL
100 mM0.0281 mL0.1404 mL0.2808 mL1.4038 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

tau hyper-phosphorylationsynaptic impairmentsneuroinflammationInhibitorinhibitGSK3βGSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3FLT3DYRK2DYRK1ACyclin dependent kinasecognitive impairmentCDK5CDKAβ oligomerAuroraKinaseAurora KinaseAurora CAurora Bactivation of astrocytes and microglia7BIO
Related Tags: buy 7BIO | purchase 7BIO | 7BIO cost | order 7BIO | 7BIO chemical structure | 7BIO formula | 7BIO molecular weight
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