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alpha-Naphthoflavone

Name: alpha-Naphthoflavone
Brand: TargetMol
SKU: T2O2744
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2O2744Cas No. 604-59-1

Alias 7,8-benzoflavone

alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.

alpha-Naphthoflavone

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Purity: 99.27%

Catalog No. T2O2744Alias 7,8-benzoflavoneCas No. 604-59-1

alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$57	In Stock	In Stock
25 mg	$94	In Stock	In Stock
50 mg	$138	In Stock	In Stock
100 mg	$209	In Stock	In Stock
500 mg	$593	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.27%

Color:White

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Product Introduction

alpha-Naphthoflavone AI Summary

alpha-Naphthoflavone exhibits diverse bioactivities across multiple biochemical and physiological pathways. It demonstrates potent inhibitory effects on several cytochrome P450 enzymes, particularly CYP1A1, CYP1A2, and CYP1B1, with IC50 values ranging from 5.0 nM to 60.0 nM. The compound shows significant enzyme inhibition in human liver microsomes and recombinant systems, indicating a strong interaction with these enzymes involved in drug metabolism. In addition to its effects on cytochrome P450 enzymes, alpha-Naphthoflavone inhibits human recombinant CYP1A2 activity with varying degrees of potency, demonstrated by IC50 values in different assay formats, some as low as 2.0 nM. It also inhibits CYP19 (aromatase) with an IC50 of 70.0 nM and shows interactions with various adenosine receptors, including moderate affinity for A1 and A2A receptors, and significant displacement activity at the A3 receptor. The compound exhibits additional inhibitory activities, including: - CYP1B1 in TCDD-stimulated human MCF7 cells, reversing anticancer drug resistance. - DNA-dependent protein kinase in HeLa cells. - Cholesterol esterase with an IC50 of 47.8 nM. - Thromboxane synthetase, PDE4 and PDE5, and transport proteins like p-glycoprotein, MRP1, and BCRP. Moreover, alpha-Naphthoflavone has shown antioxidant activity, inhibition of TCDD-induced EROD activity, and suppression of NF-kappaB activation in HCT116 cells. It exhibits differential effects on cell viability across various cell types, affecting growth rates differently in HEK293T, U2OS, and human fibroblast cells, indicating potential applications in cell growth modulation. The compound's broad spectrum of bioactivities suggests its potential therapeutic implications in enzyme inhibition, receptor interaction, and modulation of metabolic and signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.
Targets&IC50	Aromatase:5 nM(Ki)
Synonyms	7,8-benzoflavone

Chemical Properties

Molecular Weight	272.3
Formula	C₁₉H₁₂O₂
Cas No.	604-59-1
Smiles	O=C1C=C(OC2=C1C=CC1=C2C=CC=C1)C1=CC=CC=C1
Relative Density.	1.1382 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (91.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6724 mL	18.3621 mL	36.7242 mL	183.6210 mL
5 mM	0.7345 mL	3.6724 mL	7.3448 mL	36.7242 mL
10 mM	0.3672 mL	1.8362 mL	3.6724 mL	18.3621 mL
20 mM	0.1836 mL	0.9181 mL	1.8362 mL	9.1811 mL
50 mM	0.0734 mL	0.3672 mL	0.7345 mL	3.6724 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc