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W-84 dibromide
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Catalog No. T23524Cas No. 21093-51-6
Alias HDMPPA
W-84 dibromide (HDMPPA) is a M2-receptor selective modulator.
W-84 dibromide
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Purity: 95.56%
Catalog No. T23524Alias HDMPPACas No. 21093-51-6
W-84 dibromide (HDMPPA) is a M2-receptor selective modulator.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $29 | In Stock | In Stock | |
| 5 mg | $46 | In Stock | In Stock | |
| 10 mg | $73 | In Stock | In Stock | |
| 25 mg | $158 | In Stock | In Stock | |
| 50 mg | $257 | In Stock | In Stock | |
| 100 mg | $383 | In Stock | In Stock | |
| 200 mg | $545 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:95.56%
Appearance:solid
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Product Introduction
W-84 dibromide AI Summary
W-84 dibromide exhibits binding affinity and bioactivity towards the muscarinic acetylcholine receptor M2, particularly in porcine heart ventricle and cardiac tissues. It demonstrates a binding affinity characterized by a -logKa of 6.19 and cooperativity with a pAlpha of -0.47. The compound has a pAlphaKa value of 5.73 for [3H]NMS-occupied muscarinic acetylcholine receptors, indicating moderate binding affinity, and it shows an effective concentration (EC50) of approximately 1348.96 nM to inhibit [3H]NMS dissociation from the receptor. Furthermore, W-84 dibromide exhibits allosteric potency with an EC50 value of around 1440 nM and a half-life of 18.0 hours in the context of dissociating radioligand [3H]N-methylscopolamine.
The compound is moderately lipophilic, with a logP value of 1.46. It demonstrates inhibition of [3H]-N-methyl-scopolamine dissociation from porcine cardiac M2-receptors with an EC50 value of approximately 1412.54 nM. Its binding affinity varies across different experiments with Ki values ranging from 31.62 nM to 1071.52 nM. The bioactivity of W-84 dibromide includes displacement assays targeting the human muscarinic M2 receptor expressed in CHO-K9 cells, with competition binding assay Kd values ranging from 148 nM to 457 nM and Ki values in flow cytometry assays from approximately 1412 nM to 851.14 nM.
Overall, W-84 dibromide is a potential modulator of the muscarinic acetylcholine receptor M2, showing various levels of affinity and inhibitory effects in different assay conditions and receptor subtypes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | W-84 dibromide (HDMPPA) is a M2-receptor selective modulator. |
| Synonyms | HDMPPA |
| Molecular Weight | 708.52 |
| Formula | C32H44Br2N4O4 |
| Cas No. | 21093-51-6 |
| Smiles | [Br-].[Br-].C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 7.11 mg/mL (10.04 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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