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Glafenine Hydrochloride

Name: Glafenine Hydrochloride
Brand: TargetMol
SKU: T0055L
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T0055LCas No. 65513-72-6

Alias Glafenin hydrochloride

Glafenine Hydrochloride is an anti-inflammatory agent.

Glafenine Hydrochloride

🥰Excellent

Purity: 98.89%

Catalog No. T0055LAlias Glafenin hydrochlorideCas No. 65513-72-6

Glafenine Hydrochloride is an anti-inflammatory agent.

Pack Size	Price	Availability
50 mg	$33	In Stock
100 mg	$48	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Batch Information

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Purity:98.89%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Glafenine Hydrochloride is an anti-inflammatory agent.
Targets&IC50	ABCG2:3.2 μM
In vitro	Glafenine enhances the surface expression of mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in baby hamster kidney (BHK) cells, achieving 40% of the expression levels seen in wild-type CFTR[2]. Additionally, Glafenine hydrochloride suppresses the proliferation and clonogenic capabilities of human aortic smooth muscle cells (haSMCs) and endothelial cells (ECs) in a dose-responsive manner, leading to a blockade at the G2/M phase of the cell cycle and a decline in the G1 phase. Moreover, it dose-dependently impairs the migratory capacity of haSMCs and decreases the level of the extracellular matrix protein tenascin[3].
Cell Research	Glafenine hydrochloride is added to the culture medium of the smooth muscle cells at three concentrations (10 μM, 50 μM, 100 μM). After 4 days of treatment, cells are harvested and the absolute cell number is counted[3].
Synonyms	Glafenin hydrochloride

Chemical Properties

Molecular Weight	409.26
Formula	C₁₉H₁₇ClN₂O₄·HCl
Cas No.	65513-72-6
Smiles	Cl.OCC(O)COC(=O)c1ccccc1Nc1ccnc2cc(Cl)ccc12
Relative Density.	no data available
Color	Yellow
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (146.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4434 mL	12.2172 mL	24.4343 mL	122.1717 mL
5 mM	0.4887 mL	2.4434 mL	4.8869 mL	24.4343 mL
10 mM	0.2443 mL	1.2217 mL	2.4434 mL	12.2172 mL
20 mM	0.1222 mL	0.6109 mL	1.2217 mL	6.1086 mL
50 mM	0.0489 mL	0.2443 mL	0.4887 mL	2.4434 mL
100 mM	0.0244 mL	0.1222 mL	0.2443 mL	1.2217 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc