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Glafenine Hydrochloride

Name: Glafenine Hydrochloride
Brand: TargetMol
SKU: T0055L
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T0055LCas No. 65513-72-6

Alias Glafenin hydrochloride

Glafenine Hydrochloride is an anti-inflammatory agent.

Glafenine Hydrochloride

🥰Excellent

Purity: 99.03%

Catalog No. T0055LAlias Glafenin hydrochlorideCas No. 65513-72-6

Glafenine Hydrochloride is an anti-inflammatory agent.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$33	In Stock	-
100 mg	$48	In Stock	-
1 mL x 10 mM (in DMSO)	$54	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.03%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Glafenine Hydrochloride is an anti-inflammatory agent.
Targets&IC50	ABCG2:3.2 μM
In vitro	Glafenine enhances the surface expression of mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in baby hamster kidney (BHK) cells, achieving 40% of the expression levels seen in wild-type CFTR[2]. Additionally, Glafenine hydrochloride suppresses the proliferation and clonogenic capabilities of human aortic smooth muscle cells (haSMCs) and endothelial cells (ECs) in a dose-responsive manner, leading to a blockade at the G2/M phase of the cell cycle and a decline in the G1 phase. Moreover, it dose-dependently impairs the migratory capacity of haSMCs and decreases the level of the extracellular matrix protein tenascin[3].
Cell Research	Glafenine hydrochloride is added to the culture medium of the smooth muscle cells at three concentrations (10 μM, 50 μM, 100 μM). After 4 days of treatment, cells are harvested and the absolute cell number is counted[3].
Synonyms	Glafenin hydrochloride

Chemical Properties

Molecular Weight	409.26
Formula	C₁₉H₁₇ClN₂O₄·HCl
Cas No.	65513-72-6
Smiles	Cl.OCC(O)COC(=O)c1ccccc1Nc1ccnc2cc(Cl)ccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (146.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4434 mL	12.2172 mL	24.4343 mL	122.1717 mL
5 mM	0.4887 mL	2.4434 mL	4.8869 mL	24.4343 mL
10 mM	0.2443 mL	1.2217 mL	2.4434 mL	12.2172 mL
20 mM	0.1222 mL	0.6109 mL	1.2217 mL	6.1086 mL
50 mM	0.0489 mL	0.2443 mL	0.4887 mL	2.4434 mL
100 mM	0.0244 mL	0.1222 mL	0.2443 mL	1.2217 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc