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Anti-CPLX2 Antibody (3Z959)
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Catalog No. TMAY-02146
Alias Hfb1, CPX-2, CPX2, complexin 2, 921-L
Anti-CPLX2 Antibody (3Z959) is a Rabbit antibody targeting CPLX2. Anti-CPLX2 Antibody (3Z959) can be used in FCM,ICC/IF.
Anti-CPLX2 Antibody (3Z959)
Anti-CPLX2 Antibody (3Z959)
😃Good
Catalog No. TMAY-02146Alias Hfb1, CPX-2, CPX2, complexin 2, 921-L
Anti-CPLX2 Antibody (3Z959) is a Rabbit antibody targeting CPLX2. Anti-CPLX2 Antibody (3Z959) can be used in FCM,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-CPLX2 Antibody (3Z959) is a Rabbit antibody targeting CPLX2. Anti-CPLX2 Antibody (3Z959) can be used in FCM,ICC/IF. |
| Alias | Hfb1, CPX-2, CPX2, complexin 2, 921-L |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 3Z959 |
| Reactivity | Human |
| Verified Activity | 1. Immunofluorescence staining of CPLX2 in SHSY5Y cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-human CPLX2 monoclonal antibody (1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). 2. Flow cytometric analysis of Human CPLX2 expression on SHSY5Y cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human CPLX2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM,ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Complexin-2 / CPLX2 (rh Complexin-2 / CPLX2; TMPY-02025; Q6PUV4-1; Asp2-Lys134). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Complexins are unable to bind to monomeric SNARE proteins but bind with high affinity to ternary SNARE complexes and with lower affinity to target SNARE complexes. Complexin 1 (CX1) and complexin 2 (CX2) are presynaptic proteins that modulate neurotransmitter release and are used as markers of inhibitory and excitatory synapses, respectively. CPLX2 is localized in pre-synaptic terminals in mature brain. The G71-P89 region of CPLX2 is essential and sufficient for preferential axonal distribution. CPLX2 participates in the Ca(2+)-sensitive regulatory pathway for zymogen granule exocytosis. Complexin-2 is a key player in normal neurological function, and its downregulation could lead to changes in neurotransmitter release sufficient to cause significant behavioural abnormalities such as depression. It is involved in synaptogenesis and the modulation of neurotransmitter release. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Complexin-2 / CPLX2 Protein (TMPY-02025) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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