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Anti-CD86 Antibody-PE (5D537)
🥰Excellent
Catalog No. TMAY-03702P
Anti-CD86 Antibody-PE (5D537) is a PE-conjugated Mouse antibody targeting CD86. Anti-CD86 Antibody-PE (5D537) can be used in FCM.
Anti-CD86 Antibody-PE (5D537)
Anti-CD86 Antibody-PE (5D537)
🥰Excellent
Catalog No. TMAY-03702P
Anti-CD86 Antibody-PE (5D537) is a PE-conjugated Mouse antibody targeting CD86. Anti-CD86 Antibody-PE (5D537) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD86 Antibody-PE (5D537) is a PE-conjugated Mouse antibody targeting CD86. Anti-CD86 Antibody-PE (5D537) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 5D537 |
| Reactivity | Rat |
| Verified Activity | Flow cytometric analysis of rat CD86 expression on LPS-stimulated SD rat splenocytes. Cells were stained with PE-conjugated anti-rat CD86. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CD86 / B7-2 (rR CD86 / B7-2; TMPY-02016; NP_064466.1; Met1-Ile250) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/FITC/HRP |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Rat CD86 / B7-2 Protein (TMPY-02016) |
| Antigen Species | Rat |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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