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Di-O-methylhonokiol
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Catalog No. TN7231Cas No. 68592-18-7
Alias Honokiol dimethyl ether
Di-O-methylhonokiol (Honokiol dimethyl ether), a phenolic component of Magnolia grandiflora L, exhibits antimicrobial activity and significant antioxidant activity against Gram-positive and acid-resistant bacteria and fungi.
Di-O-methylhonokiol
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Purity: 99.84%
Catalog No. TN7231Alias Honokiol dimethyl etherCas No. 68592-18-7
Di-O-methylhonokiol (Honokiol dimethyl ether), a phenolic component of Magnolia grandiflora L, exhibits antimicrobial activity and significant antioxidant activity against Gram-positive and acid-resistant bacteria and fungi.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $98 | - | In Stock | |
| 5 mg | $247 | - | In Stock | |
| 10 mg | $392 | - | In Stock | |
| 25 mg | $645 | - | In Stock | |
| 50 mg | $886 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $225 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.84%
Appearance:Solid
Color:White
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Product Introduction
Di-O-methylhonokiol AI Summary
Di-O-methylhonokiol shows diverse bioactivities and potential therapeutic effects. It promotes neurite growth in rat cortical neurons, with notable activity at concentrations of 0.1 µM and 1 µM, and enhances neurite length by about 111 µM. The compound exhibits inhibitory effects on inflammatory enzymes, including 45% inhibition of COX1 in ram seminal vesicle and 47.8% inhibition of COX2 in sheep placental vesicle at an 8 µM concentration, with IC50 values of 11400.0 nM and 7700.0 nM, respectively. It also inhibits 5LOX-mediated LTB4 formation in stimulated human polymorphonuclear leukocytes, with a 27.8% inhibition and an IC50 value of 15000.0 nM. In addition, Di-O-methylhonokiol modulates the GABAAalpha1beta2 receptor by potentiating GABA-induced chloride current, exhibiting an EC50 of 42100.0 nM and maximal potentiation of 368% at 30 µM concentration.
The compound has a high octanol-water partition coefficient (log P) of around 5.69, indicating higher hydrophobicity and potential for good membrane permeability. It shows antiproliferative activity against various human and mouse cell lines, including HUVEC, HepG2, LL/2, MCF7, CNE2Z, and I10 cells, with IC50 values indicating limited potency, generally above 100,000.0 nM. Di-O-methylhonokiol also demonstrates significant inhibition of LPS-induced COX2-mediated PGF1 production and NO production in mouse RAW264.7 cells, displaying cytotoxicity at higher concentrations. Furthermore, it acts as a CB2 receptor ligand with a Ki value of 1375.0 nM, showcasing its moderate affinity for this receptor.
Overall, Di-O-methylhonokiol demonstrates a broad spectrum of bioactivities, including inflammation modulation, receptor activity modulation, and limited antiproliferative effects, with moderate hydrophobicity and potential membrane permeability..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Di-O-methylhonokiol (Honokiol dimethyl ether), a phenolic component of Magnolia grandiflora L, exhibits antimicrobial activity and significant antioxidant activity against Gram-positive and acid-resistant bacteria and fungi. |
| Synonyms | Honokiol dimethyl ether |
| Molecular Weight | 294.39 |
| Formula | C20H22O2 |
| Cas No. | 68592-18-7 |
| Smiles | O(C)C1=C(C=C(CC=C)C=C1)C2=CC(CC=C)=C(OC)C=C2 |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.95 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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